🧫
Summary-based Mendelian randomization analysis
active
experiment
Created: 2026-04-11T00:50:30
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-d1046426-5875-4c02-8657-b973f2d4218a
🧫 Experiment Protocol
ExploratoryAlzheimer's diseaseDACT1, DAAM1, KCNJ3human genetic data - summary statisticsproposed
Summary-based Mendelian randomization (SMR) analysis to establish causal relationships between genetic variants, gene expression, and biomarker levels. This analysis used GWAS summary statistics integrated with brain quantitative trait loci (QTL) data to identify putative causal mediators. The SMR approach helps distinguish between direct causal effects and linkage disequilibrium confounding, providing stronger evidence for biological causality.
PRIMARY OUTCOME
causal relationships between variants, expression, and biomarkers
EXPECTED OUTCOMES
Identification of causal mediators linking genetic variation to biomarker expression through gene regulation
SUCCESS CRITERIA
significant SMR associations with evidence of colocalization
PROTOCOL
SMR analysis using GWAS summary statistics and brain QTL data, colocalization analysis
LINKED HYPOTHESES
Source: PMID 41804841 ↗
🧫 Experiment Extras
PATHWAY
causal gene regulation, brain QTL effects
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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