🧫
ZNF263-mediated LINC00599 transcriptional regulation
active
experiment
Created: 2026-04-10T03:37:35
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-d409cfbd-2257-498c-a36c-655fc599894e
🧫 Experiment Protocol
ExploratoryPulmonary hypertensionLINC00599Cell-based transcriptional assaysproposed
This study investigated the upstream regulation of LINC00599 expression and identified that its transcription is driven by a super-enhancer mediated by the transcription factor ZNF263. The research examined the regulatory mechanisms controlling LINC00599 expression levels, which is important for understanding how this long noncoding RNA becomes upregulated in pulmonary hypertension. The identification of ZNF263 as a key transcriptional regulator provides insight into the hierarchical control of LINC00599 expression and suggests additional potential therapeutic targets in the regulatory pathway.
PRIMARY OUTCOME
LINC00599 transcriptional activity
EXPECTED OUTCOMES
ZNF263 drives LINC00599 expression through super-enhancer mechanism
SUCCESS CRITERIA
Demonstration of ZNF263-dependent LINC00599 transcriptional activation
PROTOCOL
Analysis of ZNF263-mediated super-enhancer regulation of LINC00599 transcription
Source: PMID 40693377 ↗
🧫 Experiment Extras
PATHWAY
Transcriptional regulation via super-enhancer
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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