🧫
Bidirectional Mendelian randomization analysis of C1Q and ischemic stroke
active
experiment
Created: 2026-04-06T12:27:57
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-e6c25d2e-e478-4c59-9b89-c8f63b21f996
🧫 Experiment Protocol
ExploratoryIschemic stroke (large artery atherosclerosis)C1Qhuman genetic dataproposed
A bidirectional Mendelian randomization (MR) analysis was performed to investigate the causal relationship between complement component C1Q and ischemic stroke, specifically large artery atherosclerosis subtype. C1Q was used as the exposure variable and ischemic stroke as the outcome. Inverse variance weighting (IVW) was employed as the main analytical method. The analysis utilized genetic instrumental variables to assess causality while minimizing confounding factors. This approach leverages genetic variants associated with C1Q levels to determine whether C1Q has a causal effect on ischemic stroke risk, providing evidence for the clinical relevance of the complement pathway in cerebrovascular disease.
PRIMARY OUTCOME
Causal association between C1Q and ischemic stroke risk
EXPECTED OUTCOMES
Positive association between genetic risk of C1Q and ischemic stroke
SUCCESS CRITERIA
Statistically significant odds ratio with p-value < 0.05
PROTOCOL
Bidirectional Mendelian randomization using inverse variance weighting (IVW) method
LINKED HYPOTHESES
Source: PMID 38179058 ↗
🧫 Experiment Extras
PATHWAY
Complement pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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