🧫
Spatial transcriptomic analysis of multistage ESCC development
active
experiment
Created: 2026-04-10T14:38:54
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-e6cdf2ea-4518-4cb6-8a05-0fc98103555b
🧫 Experiment Protocol
Exploratoryesophageal squamous-cell carcinomaEFNB1, EPHB4, TP53, TP63human patients and miceproposed
Spatial transcriptomic analysis was performed on samples from multistage esophageal squamous-cell carcinoma (ESCC) from both mice and humans to investigate spatiotemporal gene expression patterns and cell-cell interactions during cancer development and progression. The study aimed to decipher the molecular mechanisms that trigger epithelial-mesenchymal transition (EMT) and proliferation in epithelial cancer formation. The analysis focused on identifying aberrant epithelial cell interactions and their role in cancer progression from early precancerous lesions to invasive carcinoma.
PRIMARY OUTCOME
spatiotemporal gene expression patterns and cell-cell interactions
EXPECTED OUTCOMES
identification of molecular mechanisms triggering EMT and proliferation in epithelial cancer
SUCCESS CRITERIA
detection of aberrant epithelial cell interactions and associated signaling pathways
PROTOCOL
spatial transcriptomic sequencing and analysis of multistage ESCC samples
LINKED HYPOTHESES
Source: PMID 38097539 ↗
🧫 Experiment Extras
PATHWAY
EFNB1-EPHB4 signaling, SRC/ERK/AKT signaling, TP53-TP63/ΔNP63 axis
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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