Exploratory experiment designed to discover new patterns targeting EFNB1, EPHB4, TP53, TP63 in human patients and mice. Primary outcome: spatiotemporal gene expression patterns and cell-cell interactions
Spatial transcriptomic analysis was performed on samples from multistage esophageal squamous-cell carcinoma (ESCC) from both mice and humans to investigate spatiotemporal gene expression patterns and cell-cell interactions during cancer development and progression. The study aimed to decipher the molecular mechanisms that trigger epithelial-mesenchymal transition (EMT) and proliferation in epithelial cancer formation. The analysis focused on identifying aberrant epithelial cell interactions and their role in cancer progression from early precancerous lesions to invasive carcinoma.
spatial transcriptomic sequencing and analysis of multistage ESCC samples
identification of molecular mechanisms triggering EMT and proliferation in epithelial cancer
detection of aberrant epithelial cell interactions and associated signaling pathways
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