Validation experiment designed to validate causal mechanisms targeting CD2AP in mice. Primary outcome: cerebrovascular function parameters
Comprehensive analysis of cerebrovascular function in mice with reduced brain endothelial CD2AP, including blood flow regulation at rest and during neurovascular coupling. The study examined mural cell activity and vascular responses, revealing altered blood flow regulation and defects in mural cell function. Sex-dependent differences were observed in vascular responses to amyloid-β treatment.
measurement of blood flow regulation, neurovascular coupling, mural cell activity assessment
altered blood flow regulation and mural cell defects
significant changes in cerebrovascular parameters compared to controls
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