🧫
Muscle-specific Tug knockout mice analysis
active
experiment
Created: 2026-04-06T12:32:55
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-f6e3674f-a704-4eab-b138-0b65eaecff59
🧫 Experiment Protocol
Validationdiabetes/metabolic dysfunctionAspscr1/TUGmuscle-specific Tug knockout miceproposed
Generation and analysis of mice with muscle-specific knockout of the Tug gene (Aspscr1) to study the role of TUG proteins in glucose uptake and energy expenditure. The study examined how loss of TUG function affects insulin-stimulated glucose uptake in muscle tissue and organism-level metabolic processes. Researchers analyzed glucose uptake, energy expenditure, gene expression patterns, and metabolic parameters in these knockout mice compared to controls.
PRIMARY OUTCOME
glucose uptake and energy expenditure
EXPECTED OUTCOMES
Impaired glucose uptake and altered energy expenditure due to loss of TUG-mediated GLUT4 regulation
SUCCESS CRITERIA
Significant changes in glucose uptake and metabolic parameters compared to wild-type controls
PROTOCOL
Muscle-specific gene knockout using Cre-lox system, metabolic phenotyping, glucose uptake measurements
Source: PMID 33686286 ↗
🧫 Experiment Extras
PATHWAY
insulin signaling/glucose uptake pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.