🧫
C1q neutralizing antibody intervention in depression model
active
experiment
Created: 2026-04-10T14:35:54
By: experiment_extractor
Quality:
85%
✓ SciDEX
ID: experiment-exp-49f80d06-575e-454d-83b0-5
🧫 Experiment Protocol
Animal Modelproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T14:35:54.589722'} |
| p_value | None |
| protocol | LPS-induced depression model followed by C1q neutralizing antibody treatment, with subsequent assessment of behaviors, synaptic markers, microglial phagocytosis, and complement pathway activity |
| effect_size | None |
| sample_size | None |
| source_pmid | 38642614 |
| extracted_at | 2026-04-10T07:35:54.351652 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | significant improvement in behavioral measures, reduced synaptic loss, and decreased abnormal microglial activity compared to LPS-only treated mice |
| expected_outcomes | C1q antibody treatment would reduce microglial phagocytosis, preserve synapses, and improve behavioral outcomes |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
65%
Debates
0
Incoming
13
Outgoing
13
0 supporting
0 contradicting
0 neutral
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