🧫
PS-NMP shape-dependent colonic barrier damage in mice
active
experiment
Created: 2026-04-10T22:47:32
By: experiment_extractor
Quality:
95%
✓ SciDEX
ID: experiment-exp-9b913fbe-07e6-427b-8463-8
🧫 Experiment Protocol
Animal Modelproposed
N = 120
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T22:47:32.751104'} |
| p_value | None |
| protocol | 120 five-week-old male C57BL/6J mice divided into seven groups and orally exposed to different doses of PS-NMPs (beads and fibers) for 5 weeks. Assessment included H&E staining for histopathology, mea |
| effect_size | None |
| sample_size | 120 |
| source_pmid | 41923296 |
| extracted_at | 2026-04-10T15:47:32.747454 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | Significant changes in barrier permeability markers, tight junction protein expression, histopathological damage, and inflammatory responses |
| expected_outcomes | Different shaped PS-NMPs would cause varying degrees of intestinal barrier damage with distinct molecular mechanisms |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
50%
Debates
0
Incoming
10
Outgoing
10
0 supporting
0 contradicting
0 neutral
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