🧫
Fatty acid desaturation pathway regulation of VLC ceramide production
active
experiment
Created: 2026-04-10T14:38:37
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-33a68f6e-ded5-4012-bcd1-ea4cf42f92d1
🧫 Experiment Protocol
ExploratoryinflammationIL-10 signaling-deficient cellsproposed
Investigation of the metabolic mechanism by which IL-10 controls VLC ceramide accumulation. The study examined how IL-10 signaling regulates metabolic flux through the de novo mono-unsaturated fatty acid synthesis pathway and its impact on saturated VLC ceramide production. Researchers tested whether restoring mono-unsaturated fatty acid availability to IL-10 signaling-deficient cells could limit saturated VLC ceramide production and associated inflammation.
PRIMARY OUTCOME
VLC ceramide levels and inflammatory response
EXPECTED OUTCOMES
Restoring mono-unsaturated fatty acid availability reduces VLC ceramide production and inflammation
SUCCESS CRITERIA
Demonstration that fatty acid availability controls VLC ceramide levels and inflammatory responses
PROTOCOL
Analysis of fatty acid synthesis pathway flux, measurement of mono-unsaturated fatty acid levels, assessment of VLC ceramide production, and evaluation of inflammatory markers
Source: PMID 38383790 ↗
🧫 Experiment Extras
PATHWAY
de novo mono-unsaturated fatty acid synthesis, sphingolipid metabolism
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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