🧫
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel disease
active
experiment
Created: 2026-04-10T14:38:37
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-5eca67bb-dc0a-4b0e-86e1-16e0689132ff
🧫 Experiment Protocol
Validationinflammatory bowel diseaseIL10IL-10 knockout miceproposed
Investigation of how IL-10 deficiency leads to inflammatory bowel disease through accumulation of very long chain (VLC) ceramides. The study examined IL-10 knockout mice to understand the mechanistic link between loss of IL-10 signaling and the development of life-threatening inflammatory bowel disease. Researchers analyzed the role of saturated VLC ceramides in driving the heightened inflammatory gene expression characteristic of IL-10 deficiency.
PRIMARY OUTCOME
Development of inflammatory bowel disease and VLC ceramide levels
EXPECTED OUTCOMES
IL-10 deficient mice develop inflammatory bowel disease with increased VLC ceramide accumulation
SUCCESS CRITERIA
Demonstration of causal link between IL-10 deficiency, VLC ceramide accumulation, and inflammatory disease
PROTOCOL
Analysis of IL-10 deficient mice for inflammatory phenotypes, measurement of VLC ceramide levels, and assessment of inflammatory gene expression
LINKED HYPOTHESES
Source: PMID 38383790 ↗
🧫 Experiment Extras
PATHWAY
IL-10 anti-inflammatory signaling pathway, sphingolipid metabolism
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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