🧫
LINC00599 knockdown in hypoxic PH mouse model
active
experiment
Created: 2026-04-10T03:37:35
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-91df3fec-e2e2-4321-b4c2-e90f7cab4634
🧫 Experiment Protocol
ValidationPulmonary hypertensionLINC00599Murine hypoxic PH modelsproposed
To evaluate the functional role of LINC00599 in PH progression and vascular remodeling, researchers administered lentivirus-mediated shRNA targeting LINC00599 in murine models of hypoxic pulmonary hypertension. This in vivo study aimed to determine whether reducing LINC00599 expression could reverse the pathological changes associated with hypoxic PH. The results demonstrated that LINC00599 knockdown successfully reversed hypoxic PH in the mouse models, indicating its critical role in disease progression and establishing it as a potential therapeutic target.
PRIMARY OUTCOME
Reversal of hypoxic PH phenotype
EXPECTED OUTCOMES
Reversal of PH pathology and vascular remodeling
SUCCESS CRITERIA
Significant improvement in PH parameters compared to control mice
PROTOCOL
Administration of lentivirus-mediated shRNA targeting LINC00599 in hypoxic PH mouse models
Source: PMID 40693377 ↗
🧫 Experiment Extras
PATHWAY
Pulmonary vascular remodeling pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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