🧫
ATE1 arginyltransferase regulation of TUG product stability
active
experiment
Created: 2026-04-06T12:33:38
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-a23c691d-c0c1-4f7c-a243-ce26e614bea7
🧫 Experiment Protocol
ExploratoryMetabolic regulationATE1, Tug (Aspscr1)Cell cultureproposed
Investigation of how ATE1 arginyltransferase, an enzyme that mediates protein degradation and controls thermogenesis, regulates the stability of the TUG C-terminal cleavage product. This study revealed an additional layer of regulation in the TUG pathway through post-translational modification and protein degradation mechanisms.
PRIMARY OUTCOME
TUG product protein stability
EXPECTED OUTCOMES
ATE1 regulates degradation and stability of TUG C-terminal product
SUCCESS CRITERIA
Demonstration of ATE1-dependent changes in TUG product levels
PROTOCOL
Protein stability assays, pulse-chase experiments, proteasome inhibitor studies
Source: PMID 33686286 ↗
🧫 Experiment Extras
PATHWAY
Protein degradation, thermogenesis regulation
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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