🧫
Ketamine efficacy in geriatric TRD patients
active
experiment
Created: 2026-04-10T22:47:07
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-af649f08-05f0-42a8-85f5-76ec4879d877
🧫 Experiment Protocol
Clinicaltreatment-resistant depressiongeriatric patientsproposed
Clinical evaluation of ketamine and esketamine effectiveness in elderly patients with treatment-resistant depression. This subpopulation analysis examined the antidepressant effects of NMDA receptor antagonists in geriatric patients who had failed to respond to conventional antidepressants. The study assessed both efficacy and safety profiles, considering the unique physiological and pharmacological considerations in older adults, including altered drug metabolism, increased sensitivity to side effects, and potential interactions with multiple comorbid conditions commonly present in this age group.
PRIMARY OUTCOME
antidepressant efficacy
EXPECTED OUTCOMES
Rapid antidepressant effects with acceptable safety profile in geriatric population
SUCCESS CRITERIA
Demonstration of antidepressant efficacy with manageable adverse effects
PROTOCOL
Administration of ketamine/esketamine with monitoring for efficacy and adverse effects in elderly TRD patients
Source: PMID 41935374 ↗
🧫 Experiment Extras
PATHWAY
NMDA receptor signaling
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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