🧫
Cx43-β-catenin protein-protein interaction analysis
active
experiment
Created: 2026-04-10T22:49:51
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-c10a5471-3d00-4106-923c-6d5c7de8868a
🧫 Experiment Protocol
ExploratoryTemporomandibular joint osteoarthritisCx43Cell-based protein interaction assayproposed
A protein interaction study using coimmunoprecipitation techniques to confirm direct physical interactions between Connexin 43 (Cx43) and β-catenin proteins. This experiment was crucial for establishing the molecular basis of crosstalk between Cx43 and the Wnt/β-catenin signaling pathway in the context of TMJOA pathogenesis. The study provides evidence for a direct protein-protein interaction that may explain how Cx43 influences Wnt signaling.
PRIMARY OUTCOME
Direct protein-protein interaction between Cx43 and β-catenin
EXPECTED OUTCOMES
Direct binding interaction between Cx43 and β-catenin would be detected
SUCCESS CRITERIA
Successful coimmunoprecipitation of Cx43 and β-catenin proteins
PROTOCOL
Coimmunoprecipitation experiments to detect and confirm direct physical interactions between Cx43 and β-catenin proteins
Source: PMID 41757775 ↗
🧫 Experiment Extras
PATHWAY
Wnt/β-catenin signaling
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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