🧫
Chi3l1 deletion effects on baseline glial activation in mice
active
experiment
Created: 2026-04-10T22:32:22
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-c325639d-22e6-4b5d-8fc9-6697107ba952
🧫 Experiment Protocol
Validationbaseline neuroinflammationChi3l1Chi3l1 knockout miceproposed
An animal model study examining the baseline effects of Chi3l1 gene deletion on glial cell activation in mice. The experiment assessed both astrocyte and microglial activation states in Chi3l1 knockout mice compared to wild-type controls. Results showed no effect on astrocyte activation but modest promotion of microglial activation, providing insights into the baseline role of Chi3l1 in neuroinflammation regulation.
PRIMARY OUTCOME
glial activation status
EXPECTED OUTCOMES
Chi3l1 deletion had no effect on astrocytes but modestly promoted microglial activation
SUCCESS CRITERIA
Measurable differences in glial activation markers
PROTOCOL
Comparison of astrocyte and microglial activation markers between Chi3l1 KO and WT mice
Source: PMID 33328329 ↗
🧫 Experiment Extras
PATHWAY
neuroinflammation
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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