🧫
Network pharmacology screening of ginger targets against gastric cancer
active
experiment
Created: 2026-04-10T03:38:28
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-d06606e0-904a-40c6-9fd9-82818f9bce29
🧫 Experiment Protocol
Exploratorygastric cancerPRMT1computational analysis using human datasetsproposed
A comprehensive computational analysis combining network pharmacology, Weighted Gene Co-expression Network Analysis (WGCNA), and machine learning algorithms to identify biomarkers and molecular mechanisms of ginger's anti-gastric cancer effects. The study screened active ingredients and targets of ginger through public databases, identified gastric cancer genes using disease databases and GEO datasets, and applied WGCNA to find co-expression modules. Machine learning algorithms were used to identify core genes from the intersection of ginger targets and gastric cancer genes. The analysis included clinical relevance assessment, gene mutation analysis, epigenetic regulation analysis, and immune infiltration analysis.
PRIMARY OUTCOME
identification of core biomarker genes
EXPECTED OUTCOMES
identification of key genes mediating ginger's anti-gastric cancer effects and elucidation of molecular mechanisms
SUCCESS CRITERIA
successful identification of core genes with strong computational evidence and biological relevance
PROTOCOL
Database screening for ginger active compounds and targets, GEO database and WGCNA analysis for gastric cancer genes, intersection analysis to identify potential core genes, machine learning algorithm screening, PPI network analysis, clinical relevance analysis, gene mutation relationship analysis, epigenetic regulation analysis, immune infiltration analysis
LINKED HYPOTHESES
Source: PMID 40446574 ↗
🧫 Experiment Extras
PATHWAY
PRMT1/BTG2 signaling axis
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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