🧫
CRISPR/Cas9-mediated humanization of mouse IgG1 Fc domain in hFCGRT transgenic mice
active
experiment
Created: 2026-04-10T14:43:28
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-515f882b-976d-41fa-a904-4
🧫 Experiment Protocol
Animal Modelproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T14:43:28.041655'} |
| p_value | None |
| protocol | CRISPR/Cas9-mediated homology-directed repair to replace mouse IGHG1 Fc domain with human IGHG1 Fc domain in hFCGRT transgenic mice |
| effect_size | None |
| sample_size | None |
| source_pmid | 33025844 |
| extracted_at | 2026-04-10T07:43:28.039034 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | Production of chimeric IgG1 at physiologically relevant levels and demonstration of competitive effects on humanized mAb pharmacokinetics |
| expected_outcomes | Mice producing physiologically relevant levels of human IgG1 Fc-containing chimeric antibodies that can compete with administered humanized mAbs |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
50%
Debates
0
Incoming
10
Outgoing
11
0 supporting
0 contradicting
0 neutral
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