🧪 Experiments

6 proposed experiments from the Forge — designed to validate, falsify, and explore hypotheses

6

Total Experiments

0.71

Avg Score

0.52

Avg Feasibility

171

Clinical

202

Validation

27

Falsification

All Types animal_model (7)cell_biology (8)clinical (171)computational (12)exploratory (242)falsification (27)gene_expression (6)genetic_association (16)in-vitro (4)in_vitro (2)in-vivo (5)in_vivo (8)neuropathology (14)validation (202)

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gene_expression 0.50

Temporal analysis of gene expression differences across disease progression showed diverse cellular perturbations rangin

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

gene_expression 0.50

Single nuclei transcriptomic and epigenomic profiling of 84 donors across AD pathology spectrum mapped to a common cell

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

gene_expression 0.50

Cell type-specific analysis identified early-phase loss of somatostatin+ inhibitory neurons and later-phase loss of exci

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

gene_expression 0.50

Complex gene expression differences were identified, ranging from global to cell type-specific effects with diverse temp

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

gene_expression 0.50

Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated

🧬 pro-inflammatory genes; DAM signature genes 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

gene_expression 0.50

Single nucleus RNA-seq and ATAC-seq of postmortem PD brain tissue (n=19) and controls (n=14) identified 13 microglial su

🧬 CD83 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

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