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Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inflammatory genes resembling disease-associated microglia (DAM) signature.
active
experiment
Created: 2026-04-27T23:18:28
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-09047c9e881d
🧫 Experiment Protocol
Gene ExpressionAlzheimer's diseasepro-inflammatory genes; DAM signature genesin_vivoextracted
snRNAseq analysis of 62 additional AD cases and controls; mosaic chromosomal alteration (mCA) detection
PRIMARY OUTCOME
Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inflammatory genes resembling disease-associated microglia (DAM) signature.
Source: pmid_38260600
🧫 Experiment Extras
PATHWAY
neuroinflammation; disease-associated microglia (DAM) pathway
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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