TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration
🧬 N/A
🏥 Neurodegeneration (AD/PD)
💰 $40,000
⏱ 9mo
✅ 0.78
✨ 0.80
in-vitro
Expected: TREM2 knockdown in microglia reduces astrocyte activation toward neuroprotective phenotype (reduced ...
NAD+ Boosting and SIRT1 Activation to Reverse Cellular Senescence in Neurons
🧬 N/A
🏥 Alzheimer disease
💰 $35,000
⏱ 8mo
✅ 0.78
✨ 0.80
in-vitro
Expected: NMN treatment increases NAD+/NADH ratio >2-fold, elevates SIRT1 activity, reduces SA-β-gal positivit...
SASP Factor Secretion Patterns and Their Impact on Neuronal Health
🧬 N/A
🏥 Alzheimer disease
💰 $32,000
⏱ 7mo
✅ 0.78
✨ 0.80
in-vitro
Expected: SASP-modulated co-cultures show >40% improvement in neuronal survival under stress conditions vs. un...
TLR4-NF-κB-NLRP3 Axis Inhibition in iPSC-derived Microglia for AD Prevention
🧬 N/A
🏥 Alzheimer disease
💰 $45,000
⏱ 8mo
✅ 0.78
✨ 0.80
in-vitro
Expected: Reduction in NLRP3 inflammasome activation (IL-1β, IL-18 release) by >50% and decreased neuronal apo...