🧪 Experiments

neuropathology 0.50

Quantitative neuropathology characterization of 84 donors revealed stereotyped progression of proteinopathies with infla

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

A subset of donors showed severe cellular and molecular phenotype that correlated with steeper cognitive decline.

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) integrates neuropathology, single cell and spatial genomics, a

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Using 11C-PIB PET and 18F-MK6240 PET imaging, asymptomatic ADAD mutation carriers showed significantly greater Aβ burden

🧬 APP, PSEN1, or PSEN2 (ADAD mutations) 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Phosphorylated mTOR levels in spheroids correlated with AD severity in human postmortem brains, linking pathway activati

🧬 MTOR 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Resting-state functional connectivity analysis in ADAD carriers showed increased connectivity associated with tau deposi

🧬 null 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

GPR37 was found to be upregulated in oligodendrocytes of the substantia nigra in parkinsonian mice, and prosaposin (PSAP

🧬 GPR37 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Hallmarks of the PSAP-GPR37-IL-6 axis were observed in post-mortem brain tissue from patients with Parkinson's disease,

🧬 GPR37 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Image-based quantitative neuropathology used to stratify 84 donors and generate continuous disease pseudoprogression sco

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Integrated multiomics and spatial genomics analysis of 84 human donors revealed two distinct disease phases: an early ph

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Image-based quantitative neuropathology was used to assess 84 donors spanning the AD pathology spectrum and placed them

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Phosphorylated mTOR levels in axonal spheroids correlated with AD severity in human postmortem brains.

🧬 MTOR 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Anxa1+ DANs show selective earlier loss compared to other dopaminergic neuron subtypes during PD progression.

🧬 Anxa1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

neuropathology 0.50

Identified a subtype of Sox6+ Anxa1+ dopaminergic neurons that are selectively lost earlier than other DANs in MitoPark

🧬 ANXA1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00