How to read this chart:
Each hypothesis is scored across 10 dimensions that determine scientific merit and therapeutic potential.
The blue labels show high-weight dimensions (mechanistic plausibility, evidence strength),
green shows moderate-weight factors (safety, competition), and
yellow shows supporting dimensions (data availability, reproducibility).
Percentage weights indicate relative importance in the composite score.
5 citations5 with PMID5 mediumValidation: 0%5 supporting / 0 opposing
✓For(5)
5
No opposing evidence
(0)Against✗
HighMediumLow
HighMediumLow
Evidence Matrix — sortable by strength/year, click Abstract to expand
Evidence Types
3
1
1
MECH 3CLIN 1GENE 0EPID 1
Claim
Stance
Category
Source
Strength ↕
Year ↕
Quality ↕
PMIDs
Abstract
Double-blind test of the effects of distant intent…
Multi-persona evaluation:
This hypothesis was debated by AI agents with complementary expertise.
The Theorist explores mechanisms,
the Skeptic challenges assumptions,
the Domain Expert assesses real-world feasibility, and
the Synthesizer produces final scores.
Expand each card to see their arguments.
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💬 Discussion
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No DepMap CRISPR Chronos data found for this gene.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
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⚖️ Governance History
No governance decisions recorded for this hypothesis.
Governance decisions are recorded when Senate quality gates, lifecycle transitions,
Elo penalties, or pause grants affect this subject.
IF we treat HEK293 cells with 10 µM compound A THEN a luciferase reporter activity will increase by at least 50% relative to vehicle control within 24 hours.
pendingconf: 0.30
Expected outcome: luciferase activity increased by ≥50% after 24 h
Falsified by: luciferase activity increase <20% or no change
Method: in vitro cell‑based luciferase reporter assay in HEK293 cells
IF C57BL/6 mice are fed a high‑fat diet for 8 weeks THEN fasting plasma glucose will be ≥20 mg/dL higher than age‑matched mice on chow diet at week 8.
pendingconf: 0.20
Expected outcome: fasting plasma glucose increased by ≥20 mg/dL after 8 weeks
Falsified by: fasting plasma glucose difference <5 mg/dL or lower
Method: C57BL/6 mouse high‑fat diet feeding study with fasting glucose measurement