ID: h-0bac1b92f6
Hypothesis
Complement C1q/C3 Blockade for Alzheimer's Disease
Microglia-mediated complement activation (C1q, C3) leads to excessive synaptic pruning in AD.
EvidencePending (0%)📖 0 cit🗣 1 debates✓ 4 support✗ 4 oppose
✓ All Quality Gates Passed
🧪 Overview
Microglia-mediated complement activation (C1q, C3) leads to excessive synaptic pruning in AD. Tau pathology sensitizes neurons to complement-mediated attack. Blocking C1q or C3 may prevent synapse loss independent of amyloid/tau pathology, though complement has homeostatic roles in debris clearance and plasticity.
🧬 Mechanism
No curated mechanism pathway recorded for this hypothesis.
⚖️ Evidence
⚖️ Evidence Matrix4 supports4 contradicts
Contradicts
C3-deficient AD mice show increased dystrophic neurites and impaired plaque compaction
Contradicts
C1q-mediated pruning is essential for normal brain development and adult plasticity
Contradicts
Systemic complement blockade increases infection risk (meningococcal, encapsulated bacteria)
📖 Linked Papers
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — C1QA
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for C1QA.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
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📊 Market Indicators
7d Trend
↔
Stable
7d Momentum
▼ 1.3%
Volatility
Low
0.0015
Events (7d)
4
Price History
▼7.7%💾 Resource Usage
No resource usage or linked notebooks recorded for this hypothesis yet.
Parent Context
▸Metadataorigin_type: debate_synthesizer
| origin_type | debate_synthesizer |
| target_gene | C1QA |
| _schema_version | 1 |
| composite_score | 0.619 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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