Top 50 hypotheses ranked by tournament Elo, market confidence, debate depth, and citation provenance
| # | Hypothesis | Elo | Market | Debates | Citations | Updated | Score |
|---|---|---|---|---|---|---|---|
| 🥇 |
Closed-loop transcranial focused ultrasound to restore hippocampal gamma
therapeutic
• PVALB
• alzheimers
|
211211 matches | 0.840 Market | 18 Transcript | 68 | 2026-04-27 | 0.865 |
| 🥈 |
CYP46A1 Overexpression Gene Therapy
therapeutic
• CYP46A1
• neurodegeneration
|
210570 matches | 0.919 Market | 5 Transcript | 85 | 2026-04-28 | 0.768 |
| 🥉 |
miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy
therapeutic
• miR-33/ABCA1
• molecular-biology
|
20338 matches | 0.741 Market | 1 Transcript | 8 | 2026-04-26 | 0.824 |
| 4 |
Selective Acid Sphingomyelinase Modulation Therapy
therapeutic
• SMPD1
• neurodegeneration
|
200571 matches | 0.920 Market | 5 Transcript | 83 | 2026-04-27 | 0.782 |
| 5 |
Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation
therapeutic
• HCRTR1/HCRTR2
• neurodegeneration
|
185667 matches | 0.841 Market | 2 Transcript | 50 | 2026-04-26 | 0.882 |
| 6 |
Closed-loop focused ultrasound targeting EC-II SST interneurons to resto
therapeutic
• SST
• alzheimers
|
185010 matches | 0.900 Market | 18 Transcript | 50 | 2026-04-28 | 0.748 |
| 7 |
Beta-frequency entrainment therapy targeting PV interneuron-astrocyte co
therapeutic
• SST
• alzheimers
|
180756 matches | 0.827 Market | 18 Transcript | 57 | 2026-04-27 | 0.884 |
| 8 |
APOE-Dependent Autophagy Restoration
therapeutic
• MTOR
• neurodegeneration
|
178059 matches | 0.850 Market | 3 Transcript | 85 | 2026-04-26 | 0.895 |
| 9 |
H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Prun
therapeutic
• TREM2
• neurodegeneration
|
177724 matches | 0.563 Market hub | 5 Transcript | 11 | 2026-04-27 | 0.644 |
| 10 |
Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gam
therapeutic
• PVALB
• alzheimers
|
177010 matches | 0.831 Market | 18 Transcript | 64 | 2026-04-27 | 0.869 |
| 11 |
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescenc
therapeutic
• CYP46A1
• neurodegeneration
|
173354 matches | 0.555 Market hub | 5 Transcript | 38 | 2026-04-27 | 0.555 |
| 12 |
Closed-loop tACS targeting EC-II SST interneurons to block tau propagati
therapeutic
• SST
• alzheimers
|
170713 matches | 0.910 Market | 18 Transcript | 55 | 2026-04-28 | 0.752 |
| 13 |
Closed-loop focused ultrasound targeting CA1 PV interneurons to restore
therapeutic
• PVALB
• alzheimers
|
170124 matches | 0.602 Market hub | 18 Transcript | 50 | 2026-04-27 | 0.754 |
| 14 |
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection
therapeutic
• MAPT
• neuroscience
|
168827 matches | 0.568 Market hub | 18 Transcript | 17 | 2026-04-27 | 0.751 |
| 15 |
Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin
therapeutic
• PVALB
• alzheimers
|
168012 matches | 0.858 Market | 18 Transcript | 58 | 2026-04-28 | 0.811 |
| 16 |
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylat
therapeutic
• BDNF
• alzheimers
|
167447 matches | 0.861 Market | 18 Transcript | 11 | 2026-04-27 | 0.885 |
| 17 |
Gamma entrainment therapy to restore hippocampal-cortical synchrony
therapeutic
• SST
• alzheimers
|
167310 matches | 0.851 Market | 19 Transcript | 105 | 2026-04-27 | 0.946 |
| 18 |
AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescu
therapeutic
• PRKAA1
• neurodegeneration
|
166362 matches | 0.813 Market | 2 Transcript | 72 | 2026-04-28 | 0.833 |
| 19 |
Closed-loop transcranial alternating current stimulation to restore hipp
therapeutic
• SST
• alzheimers
|
165010 matches | 0.830 Market | 18 Transcript | 51 | 2026-04-28 | 0.603 |
| 20 |
Closed-loop transcranial focused ultrasound targeting EC-II SST interneu
therapeutic
• SST
• alzheimers
|
163044 matches | 0.706 Market hub | 18 Transcript | 50 | 2026-04-28 | 0.955 |
| 21 |
Dual NF-κB/MMP Inhibition Strategy
therapeutic
• NFKB1
• —
|
16201 matches | 0.542 Market hub | 2 Transcript | 0 | 2026-04-23 | 0.554 |
| 22 |
Senescent Microglia Resolution via Maresins-Senolytics Combination
therapeutic
• BCL2L1
• neurodegeneration
|
161839 matches | 0.664 Market | 2 Transcript | 46 | 2026-04-26 | 0.791 |
| 23 |
Blood-Brain Barrier SPM Shuttle System
therapeutic
• TFRC
• neurodegeneration
|
160418 matches | 0.533 Market | 2 Transcript | 49 | 2026-04-28 | 0.533 |
| 24 |
MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CNS-Penetrant
therapeutic
• MFSD2A (SLC59A1)
• neuropharmacology
|
15686 matches | 0.536 Market hub | 1 Transcript | 15 | 2026-04-13 | 0.551 |
| 25 |
Optogenetic restoration of hippocampal gamma oscillations via selective
therapeutic
• PVALB
• alzheimers
|
153323 matches | 0.566 Market hub | 18 Transcript | 68 | 2026-04-27 | 0.865 |
| 26 |
Neutral Sphingomyelinase-2 Inhibition for Synaptic Protection in Neurode
therapeutic
• SMPD3
• neurodegeneration
|
153212 matches | 0.844 Market | 5 Transcript | 45 | 2026-04-28 | 0.844 |
| 27 |
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Primi
therapeutic
• TLR4
• neurodegeneration
|
152311 matches | 0.806 Market | 3 Transcript | 92 | 2026-04-28 | 0.789 |
| 28 |
Epigenetic Reprogramming of Microglial Memory
therapeutic
• DNMT3A, HDAC1/2
• alzheimers
|
151624 matches | 0.678 Market | 4 Transcript | 14 | 2026-04-26 | 0.647 |
| 29 |
Closed-loop focused ultrasound targeting EC-II PV interneurons to restor
therapeutic
• PVALB
• alzheimers
|
15158 matches | 0.565 Market hub | 18 Transcript | 67 | 2026-04-27 | 0.863 |
| 30 |
Senescent Cell ASM-Complement Cascade Intervention
therapeutic
• SMPD1
• neurodegeneration
|
151212 matches | 0.920 Market hub | 5 Transcript | 54 | 2026-04-28 | 0.852 |
| 31 |
Optogenetic restoration of hippocampal gamma oscillations via selective
therapeutic
• SST
• alzheimers
|
15114 matches | 0.540 Market hub | 18 Transcript | 51 | 2026-04-27 | 0.584 |
| 32 |
Closed-loop transcranial focused ultrasound to restore hippocampal gamma
therapeutic
• CCK
• alzheimers
|
15014 matches | 0.579 Market hub | 18 Transcript | 61 | 2026-04-27 | 0.912 |
| 33 |
Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment
therapeutic
• PVALB
• alzheimers
|
15000 matches | 1.000 Market | 18 Transcript | 8 | 2026-04-27 | 0.573 |
| 34 |
Metabolic Reprogramming to Reverse Senescence
therapeutic
• SIRT1,PGC1A,NAMPT
• —
|
15000 matches | 1.000 Market | 8 Transcript | 11 | 2026-04-27 | 0.720 |
| 35 |
SASP Modulation Rather Than Cell Elimination
therapeutic
• NFKB1,IL1B,BDNF
• —
|
15000 matches | 0.981 Market | 8 Transcript | 14 | 2026-04-27 | 0.660 |
| 36 |
Autophagy-Senescence Axis Therapeutic Window
therapeutic
• ATG7,BCL2,BCL2L1
• —
|
15000 matches | 0.921 Market | 8 Transcript | 7 | 2026-04-27 | 0.624 |
| 37 |
APOE4-Specific Proteolytic Fragment Inhibition Therapy
therapeutic
• APOE
• alzheimers
|
15000 matches | 0.867 Market hub | 1 No transcript | 31 | 2026-04-28 | 0.777 |
| 38 |
CYP46A1 Small Molecule Activator Therapy
therapeutic
• CYP46A1
• neurodegeneration
|
15000 matches | 0.819 Market hub | 5 Transcript | 47 | 2026-04-28 | 0.819 no data |
| 39 |
CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven Translation
therapeutic
• CYP46A1
• neurodegeneration
|
15000 matches | 0.819 Market hub | 5 Transcript | 47 | 2026-04-28 | 0.819 no data |
| 40 |
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency
therapeutic
• HCAR2
• neurodegeneration
|
15000 matches | 0.808 Market | 1 Transcript | 11 | 2026-04-26 | 0.808 |
| 41 |
Closed-loop transcranial focused ultrasound to restore hippocampal gamma
therapeutic
• PVALB
• alzheimers
|
15000 matches | 0.750 Market hub | 18 Transcript | 65 | 2026-04-28 | 0.827 |
| 42 |
Closed-loop transcranial focused ultrasound targeting EC-II SST interneu
therapeutic
• SST
• alzheimers
|
15000 matches | 0.591 Market hub | 18 Transcript | 55 | 2026-04-27 | 0.968 |
| 43 |
Temporal Gating of Microglial Responses
therapeutic
• CLOCK, ARNTL
• alzheimers
|
15000 matches | 0.590 Market | 3 Transcript | 16 | 2026-04-26 | 0.565 |
| 44 |
Synaptic Vesicle Tau Capture Inhibition
therapeutic
• SNAP25
• alzheimers
|
15000 matches | 0.590 Market hub | 2 Transcript | 62 | 2026-04-12 | 0.578 |
| 45 |
Closed-loop optogenetic targeting PV interneurons to restore theta-gamma
therapeutic
• PVALB
• alzheimers
|
15000 matches | 0.585 Market hub | 18 Transcript | 61 | 2026-04-27 | 0.959 |
| 46 |
APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation R
therapeutic
• APOE/PVALB
• alzheimers
|
15000 matches | 0.565 Market hub | 1 No transcript | 31 | 2026-04-16 | 0.625 |
| 47 |
Real-time closed-loop transcranial focused ultrasound targeting PVALB in
therapeutic
• PVALB
• alzheimers
|
15000 matches | 0.563 Market hub | 18 Transcript | 65 | 2026-04-27 | 0.559 |
| 48 |
TREM2-Dependent Microglial Surveillance Controls AQP4-Mediated Tau Clear
therapeutic
• TREM2
• neuroscience
|
15000 matches | 0.559 Market hub | 18 Transcript | 18 | 2026-04-27 | 0.569 |
| 49 |
Optogenetic restoration of hippocampal gamma oscillations via channelrho
therapeutic
• PVALB
• alzheimers
|
15000 matches | 0.555 Market hub | 18 Transcript | 65 | 2026-04-27 | 0.555 |
| 50 |
Microglial Exosome-Mediated Tau Propagation
therapeutic
• MAPT
• neuroscience
|
15000 matches | 0.539 Market hub | 18 Transcript | 17 | 2026-04-27 | 0.539 |