📄
Immune checkpoint inhibition perturbs neuro-immune homeostasis and impairs cognitive function.
active
paper
Created: 2026-04-17T10:19:28
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: ea6a2a97-b542-4b62-9f95-000231855b9e
📄 Paper Details
Immune checkpoint inhibition perturbs neuro-immune homeostasis and impairs cognitive function.
["Onwodi V Ifejeokwu", "An H Do", "Sanad M El Khatib", "Nhu N Ho", "Angel Zavala", "Shivashankar Othy", "Munjal M Acharya"]
Abstract
BACKGROUND: Blockade of Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Cell Death Protein 1 (PD-1) significantly improves progression-free survival in patients with cancers, including melanoma. In addition to unleashing antitumor immunity, immune checkpoint inhibition (ICI) therapies disrupt immune regulatory networks critical for maintaining homeostasis in various tissues, including the central nervous system (CNS). Despite growing reports of cancer- and ICI-related cogniti...
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | papers |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.