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A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.
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📄 Paper Details
A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.
["Peserico A", "Chiacchiera F", "Grossi V", "Matrone A", "Latorre D", "Simonatto M", "Fusella A", "Ryall JG", "Finley LW", "Haigis MC", "Villani G", "Puri PL", "Sartorelli V", "Simone C"]
Abstract
Reduction of nutrient intake without malnutrition positively influences lifespan and healthspan from yeast to mice and exerts some beneficial effects also in humans. The AMPK-FoxO axis is one of the evolutionarily conserved nutrient-sensing pathways, and the FOXO3A locus is associated with human longevity. Interestingly, FoxO3A has been reported to be also a mitochondrial protein in mammalian cells and tissues. Here we report that glucose restriction triggers FoxO3A accumulation into mitochondri...
▸Metadata
| _schema_version | 1 |
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| quality_evaluation | {'agent': 'codex-slot-40', 'signals': {'pmid': '23283301', 'year': 2013, 'journal': 'Cellular and molecular life sciences : CMLS', 'usage_score': 0.5, 'abstract_present': True}, 'task_id': 'ebade91a-4 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
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