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Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase.
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ID: paper-27184631
📄 Paper Details
Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase.
["Jiang L", "Wu X", "Wang S", "Chen S", "Zhou H", "Wilson B", "Jin C", "Lu R", "Xie K", "Wang Q"]
Abstract
BACKGROUND: Clozapine, an atypical antipsychotic medication, has been effectively used to treat refractory schizophrenia. However, the clinical usage of clozapine is limited due to a high incidence of neutropenia or agranulocytosis. We previously reported that clozapine protected dopaminergic neurons through inhibition of microglial activation. The purpose of this study was to explore the neuroprotective effects of clozapine metabolites clozapine N-oxide (CNO) and N-desmethylclozapine (NDC), as ...
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📊 Evidence Profile
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