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HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway.
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📄 Paper Details
HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway.
Liao Y, Cheng J, Kong X, Li S, Li X, Zhang M, Zhang H, Yang T, Dong Y, Li J, Xu Y, Yuan Z
Abstract
Rationale: It is known that neuroinflammation plays a critical and detrimental role in the development of cerebral ischemia/reperfusion (I/R), but the regulation of the cyclic GMP-AMP synthase (cGAS)-mediated innate immune response in I/R-induced neuroinflammation is largely unexplored. This study aimed to investigate the function and regulatory mechanism of cGAS in I/R-induced neuroinflammation and brain injury, and to identify possible strategies for the treatment of ischemic stroke. Methods: ...
▸Metadata
| doi | 10.7150/thno.47651 |
| pmid | 32863951 |
| year | 2020 |
| pmc_id | None |
| _origin | {'url': 'https://pubmed.ncbi.nlm.nih.gov/32863951/', 'type': 'external', 'tracked_at': '2026-04-23T20:17:17.647748'} |
| authors | ['Liao Y', 'Cheng J', 'Kong X', 'Li S', 'Li X', 'Zhang M', 'Zhang H', 'Yang T', 'Dong Y', 'Li J', 'Xu Y', 'Yuan Z'] |
| journal | Theranostics |
| _schema_version | 1 |
| quality_scoring | {'quality_status_review': {'status': 'pass', 'signals': ['has_provenance_chain', 'has_metadata'], 'task_id': '3854fa92-f632-4cba-be41-396420da7151', 'rationale': 'quality_status assigned by automated |
📊 Evidence Profile
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5%
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