📄
Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-40894745
📄 Paper Details
Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling.
Redmon SN, Yarishkin O, Rudzitis CN, Lakk M, Bertrand J, van Batenburg-Sherwood J, Nicou CM, Passaglia CL, Overby DR, Križaj D
Abstract
Clinicians are often forced into the dilemma of whether to battle ocular inflammation or preserve vision imperiled by elevated intraocular pressure (IOP). Anti-inflammatory treatments utilizing glucocorticosteroid regimens may induce glaucoma by chronically elevating IOP via increased trabecular meshwork (TM) resistance to the flow of aqueous humor, but it is not known whether pressure transduction itself is impacted by steroids and how changes in TM mechanosignaling affect conventional outflow ...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.