Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies.

Piezo1, a trimeric mechanosensitive cation channel discovered in 2010 and recognized with the 2021 Nobel Prize for its seminal role in mechanotransduction, has emerged as a key transducer of mechanical forces into calcium ions (Ca2+) signaling. Its distinctive propeller-like structure confers high mechanosensitivity, enabling rapid and graded Ca2+ influx under diverse mechanical stimuli such as shear stress, stretch, or compression. This Ca2+ entry establishes localized nanodomains and amplifies...