Effects of post-stress corticosterone on hippocampal excitability and behavior involving hyperpolarization-activated cation channel 1 function.

Single Prolonged Stress (SPS) is a widely used rodent model for investigating the consequences of acute traumatic stress, but outcomes in mice are often variable across strains and behavioral domains. Because corticosterone (CORT) release is a central feature of the stress response, we combined SPS with post-stress CORT administration (SPS + CORT) to capture this hormonal component and unmask latent phenotypes. Hyperpolarization-activated cyclic nucleotide-gated 1 (HCN1) channels are highly expr...