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FIGURE 1: Ovarian CSCs exhibit enhanced mitophagy. (A, B) Mitochondrial mass was evaluated...
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Created: 2026-04-22T16:25:26
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FIGURE 1Figure 1
Ovarian CSCs exhibit enhanced mitophagy. (A, B) Mitochondrial mass was evaluated in spheroid and adherent cultured ovarian cancer cells. OVCAR3 and OVCAR4 cells cultured under serum‐free spheroid or serum‐containing adherent culture conditions were stained with MitoTracker Green and analysed using flow cytometry. n = 3, bar: SD, * p < 0.05, p < 0.01. (C–E) Mitochondria‐associated LC3 levels were assessed in ovarian CSCs. Mitochondria were isolated from a panel of spheroid and adherent cultured ovarian cancer cell lines (C), ALDH + and ALDH − cells sorted from the OVCAR3 cell line (D), and CD44 + CD117 + and CD44 − CD117 − cells sorted from the OVCAR4 cell line, immunoblotting was conducted to assess LC3 expression levels. (F, G) Confocal images of MitoTracker Green labelled mitochondria and of RFP‐labelled LC3 in adherent and spheroid cultured ovarian cancer cells. OVCAR3 cells were stably transfected with LC3‐RFP, cultured under either spheroid or adherent conditions. Cells w
▸Metadata
| doi | 10.1111/jcmm.70704 |
| pmcid | PMC12516242 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12516242/bin/JCMM-29-e70704-g005.jpg', 'type': 'external', 'tracked_at': '2026-04-22T23:25:26.814679'} |
| caption | Ovarian CSCs exhibit enhanced mitophagy. (A, B) Mitochondrial mass was evaluated in spheroid and adherent cultured ovarian cancer cells. OVCAR3 and OVCAR4 cells cultured under serum‐free spheroid or s |
| paper_id | d46a46a8-3f6d-499f-aca4-f80e82536942 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12516242/bin/JCMM-29-e70704-g005.jpg |
| image_path | |
| description | |
| figure_label | FIGURE 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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