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Fig. 4 — Implications of virus-induced stress granules in tauopathies.
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Created: 2026-04-21T18:29:40
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ID: paper-fig-paper-20c25378c765-4
Fig. 4Figure 4
Stress granules as a hub for tau and virus interactions. The schematic depicts the molecular interactions and processes by which viruses and endogenous retroelements contribute to the dysregulation, aggregation, and intracellular propagation of tau. Stress granule (SG)-associated proteins (purple) that are predicted to influence both tau and viruses are shown in key pathways. In the secreting cell, native tau affects the expression of endogenous retroviruses (ERVs), long interspersed nuclear elements (LINEs), and short interspersed nuclear elements (SINEs) with ERVs possibly affecting SG dynamics. SGs serve as the center element where STAU1 and DDX6 interact directly with tau. Inflammasomes inhibit SG formation by sequestering DDX3X and G3BP1. Viral infections by HSV-1, HIV, and HTLV-1 further influence tau pathology by modifying the stability, splicing and pathways of degradation of tau. TRIM-21 is associated with tau degradation and neutralization of viruses. Conversely, HSP90 plays
▸Metadata
| pmid | paper-20c25378c765 |
| caption | Stress granules as a hub for tau and virus interactions. The schematic depicts the molecular interactions and processes by which viruses and endogenous retroelements contribute to the dysregulation, a |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12896018/bin/40035_2026_538_Fig4_HTML.jpg |
| paper_title | Implications of virus-induced stress granules in tauopathies. |
| figure_label | Fig. 4 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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