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FIGURE 1 — Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophys
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Created: 2026-04-21T18:29:40
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FIGURE 1Figure 1
Oxidative stress in CGNs of FRDA mouse model. (A) The picture shows the loading of 1 μM CM-H 2 Xros in CGNs. (B) The graph shows the kinetic curves normalized, for Control (black) and YG8R (red). (C) The histogram represents the rates of ArbU over minutes in percentage normalized to the Control. mROS were significantly increased in YG8R CGNs compared to Control ( ∗ p < 0.05). (D) The picture shows CGNs loaded with 10 μM C11 BODIPY (581/591), top left bright field (bf), at 0 minutes it is shown the oxidized form (top green), the un-oxidized form (top red) and the merge; at 9 min fluorescence it is shown the oxidized form increased (bottom green), the un-oxidized form decreased (bottom red) and the merge. (E,F) Show respectively the kinetic curves and the rates the lipid peroxidation ( ∗∗∗ p < 0.0005). Scale bar (20 μm).
▸Metadata
| pmid | paper-eba56eb9e84f |
| caption | Oxidative stress in CGNs of FRDA mouse model. (A) The picture shows the loading of 1 μM CM-H 2 Xros in CGNs. (B) The graph shows the kinetic curves normalized, for Control (black) and YG8R (red). |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC6176067/bin/fncel-12-00264-g001.jpg |
| paper_title | Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophysiology. |
| figure_label | FIGURE 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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