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Figure 6.: Interpreting noncoding risk variants of mental diseases and traits. (A) LDSC ana...
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Created: 2026-04-27T05:03:09
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Figure 6.Figure 6
Interpreting noncoding risk variants of mental diseases and traits. (A) LDSC analysis results showing the risk variants associated with neuropsychiatric disorders and traits enrichment in three histone modification peaks from each major basal ganglia subclass. *FDR < 0.1; **FDR < 0.05; *** FDR < 0.01. (B) Heatmap showing enrichment of risk variants associated with neuropsychiatric disorders and traits in three histone modification peaks from each MSN group. *FDR < 0.1; **FDR < 0.05; *** FDR < 0.01. (C) Table showing the number of fine-mapped variants (PIP >0.1), number of cCREs overlapping with those variants, number of target genes linked with variants overlapping cCREs from ABC model, and cell types with top LDSC enrichment (FDR < 0.1) for selected diseases and traits. (D) Characterization of fine-mapped schizophrenia risk variant rs2440389 in a H3K27ac-marked enhancer. Genome browser tracks showing three histone modification profiles in five subclasses. Chromatin interaction tracks
▸Metadata
| doi | 10.64898/2026.02.03.703645 |
| pmcid | PMC12893060 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12893060/bin/nihpp-2026.02.03.703645v1-f0006.jpg', 'type': 'external', 'tracked_at': '2026-04-27T12:03:09.444502'} |
| caption | Interpreting noncoding risk variants of mental diseases and traits. (A) LDSC analysis results showing the risk variants associated with neuropsychiatric disorders and traits enrichment in three histon |
| paper_id | paper-pm-41684930 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12893060/bin/nihpp-2026.02.03.703645v1-f0006.jpg |
| image_path | |
| description | |
| figure_label | Figure 6. |
| figure_number | 6 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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