| sess_SDA-2026-04-26- | What blood-brain barrier permeability changes serve as early biomarkers for neur | 1.00 | 7 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc |
| sess_SDA-2026-04-26- | How do ALS-linked UBQLN2 mutations affect its ubiquitylation-dependent stability | 0.78 | 3 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-181402-259766ab |
| sess_SDA-2026-04-26- | Blood-brain barrier permeability changes as early biomarkers for neurodegenerati | 0.78 | 3 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001501 |
| sess_SDA-2026-04-26- | Are age-related DNA methylation changes protective adaptations or pathological d | 0.78 | 3 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260410-112902-5b3fc173 |
| sess_SDA-2026-04-26- | Are DNA methylation changes in neurodegeneration causal drivers or protective co | 0.78 | 3 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260410-111542-7f40fe3e |
| sess_SDA-2026-04-26- | How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen | 0.78 | 3 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gap-20260425-224724 |
| sess_hypdebate_h_45d | Hypothesis debate: Multi-Biomarker Composite Index Surpassing Amyloid PET for Tr | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-16-gap-pubmed-20260410-192526-f2bbb9ab |
| sess_hypdebate_h_cef | Hypothesis debate: Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-002 | 0.50 | 1 | 4 | completed | 2026-04-26 | |
| sess_hypdebate_h_cef | Hypothesis debate: Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-002 | 0.50 | 1 | 4 | completed | 2026-04-26 | |
| sess_hypdebate_h_0f0 | Hypothesis debate: PLCG2 Allosteric Modulation as a Precision Therapeutic for TR | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-01-gap-001 |
| sess_hypdebate_h_0f0 | Hypothesis debate: PLCG2 Allosteric Modulation as a Precision Therapeutic for TR | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-01-gap-001 |
| sess_hypdebate_h_var | Hypothesis debate: Closed-loop optogenetic targeting PV interneurons to restore | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-03-26abc5e5f9f2 |
| sess_hypdebate_h_var | Hypothesis debate: Closed-loop transcranial focused ultrasound targeting EC-II S | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-03-26abc5e5f9f2 |
| sess_hypdebate_h_611 | Hypothesis debate: TREM2-Dependent Microglial Senescence Transition | 0.64 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-26-trem2-showcase |
| sess_hypdebate_SDA_2 | Hypothesis debate: SASP Modulation Rather Than Cell Elimination | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| sess_hypdebate_h_var | Hypothesis debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegene | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-26-trem2-showcase |
| sess_hypdebate_h_var | Hypothesis debate: Closed-loop transcranial focused ultrasound with 40Hz gamma e | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-03-26abc5e5f9f2 |
| sess_hypdebate_SDA_2 | Hypothesis debate: Metabolic Reprogramming to Reverse Senescence | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| sess_hypdebate_SDA_2 | Hypothesis debate: Metabolic Reprogramming to Reverse Senescence | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| sess_hypdebate_h_d5d | Hypothesis debate: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes | 0.60 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| sess_hypdebate_h_495 | Hypothesis debate: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propag | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| sess_hypdebate_h_8d1 | Hypothesis debate: Enteric Nervous System Dysfunction as Self-Reinforcing Pathol | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| sess_hypdebate_h_f81 | Hypothesis debate: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target | 0.50 | 1 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| sess_SDA-2026-04-26- | What are the key mechanistic, therapeutic, and diagnostic dimensions of TREM2 in | 0.92 | 7 | 4 | completed | 2026-04-26 | SDA-2026-04-26-trem2-showcase |
| sess_SDA_2026_04_26_ | What are the key molecular mechanisms by which gut microbiome dysbiosis drives n | 1.00 | 4 | 4 | completed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| sess_SDA-2026-04-26- | What are the mechanisms by which microglial senescence contributes to ALS pathol | 0.75 | 4 | 6 | completed | 2026-04-26 | SDA-2026-04-26-gap-20260425215446 |
| sess_SDA-2026-04-26- | Blood-brain barrier permeability changes as early biomarkers for neurodegenerati | 0.50 | 0 | 7 | completed | 2026-04-26 | SDA-2026-04-26-gap-bbb-permeability-biomarker-20260426 |
| sess_SDA-2026-04-25- | Do connectivity motifs predict which cell types in a neurodegenerative mouse mod | 0.50 | 0 | 4 | completed | 2026-04-25 | SDA-2026-04-25-allen-zeng-connectivity-vulnerability-circuit |
| sess_SDA-2026-04-25- | Microglial senescence in Alzheimer and Parkinson disease progression | 0.50 | 0 | 6 | completed | 2026-04-25 | SDA-2026-04-25-gap-20260425234323 |
| paper_debate_paper-3 | What are the scientific significance and neurodegeneration implications of: Anta | 0.72 | 3 | 4 | completed | 2026-04-25 | |
| paper_debate_paper-4 | What are the scientific significance and neurodegeneration implications of: Tau | 0.72 | 4 | 4 | completed | 2026-04-25 | |
| paper_debate_paper-3 | What are the scientific significance and neurodegeneration implications of: Beyo | 0.72 | 3 | 4 | completed | 2026-04-25 | |
| sess_SDA-2026-04-25- | Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration | 0.50 | 0 | 5 | completed | 2026-04-25 | SDA-2026-04-25-gap-epi-clock-biomarker-20260425-222549 |
| sess-gap-pubmed-2026 | What are the optimal oxygen pressure, duration, and frequency parameters for HBO | 0.68 | 7 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-181340-8acb24dc-debate |
| sess-gap-pubmed-2026 | What mechanisms drive the self-amplifying vicious cycle linking oxidative stress | 0.84 | 6 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-181140-0af1a353-debate |
| sess-gap-pubmed-2026 | Does restoring neuronal AMPK activity reverse microglial inflammation in vivo? | 0.77 | 7 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-180918-962b1ada-debate |
| sess-gap-pubmed-2026 | Can ferroptosis inhibitors prevent BBB disruption and edema formation after card | 0.73 | 7 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| sess-gap-pubmed-2026 | Which specific factors in conditioned medium from healthy astrocytes rescue moto | 0.65 | 7 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |
| sess-gap-pubmed-2026 | Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other | 0.66 | 8 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| sess-gap-pubmed-2026 | How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what | 0.66 | 5 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| sess-gap-pubmed-2026 | Which specific CSF molecular components are essential for maintaining disease-re | 0.66 | 3 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-081644-1d2624b8-debate |
| sess-gap-pubmed-2026 | Which specific transcription factors mediate MAPT suppression during proteostati | 0.66 | 3 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-083749-7d0cea3d-debate |
| sess-gap-pubmed-2026 | What specific autophagy pathways are defective in radiation-induced pericyte sen | 0.66 | 3 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-193006-9525a13b-debate |
| sess-gap-pubmed-2026 | How does parthenolide specifically modulate ADORA2A signaling to produce antidep | 0.66 | 3 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-193037-1dc5e03a-debate |
| sess-gap-pubmed-2026 | What is the molecular mechanism by which rutin inhibits tau aggregation and olig | 0.66 | 3 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-085530-9015d285-debate |
| sess-gap-pubmed-2026 | Does RGS6 upregulation or D2 autoreceptor modulation prevent neurodegeneration i | 0.54 | 5 | 4 | completed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-145520-5692b02e-debate |
| sess_gap-pubmed-2026 | What is the minimum effective dose of trazodone required for disease-modifying e | 0.64 | 6 | 4 | completed | 2026-04-25 | |
| sess_gap-debate-2026 | Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ | 0.69 | 7 | 4 | completed | 2026-04-25 | |
| sess_SDA-2026-04-25- | Does tau dendritic missorting persist independently after Aβ clearance, maintain | 0.65 | 7 | 4 | completed | 2026-04-25 | SDA-2026-04-25-gapdebate-98a600b3ed |
| sess_SDA-2026-04-25- | Does pericyte senescence drive BBB breakdown or result from neurodegeneration as | 0.68 | 6 | 4 | completed | 2026-04-25 | SDA-2026-04-25-gapdebate-de5dfc4391 |