| gap-pubmed-20260410- | Which fluid biomarkers can serve as valid surrogates for cognitive outcomes acro | open | 0.83 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-pubmed-20260410- | What target engagement biomarkers can be developed for synaptic plasticity and n | open | 0.80 | 0.00 | 2026-04-10 | 0 | | synaptic-biology |
| gap-pubmed-20260410- | Why do positive CSF tau biomarker changes from anti-tau treatments fail to trans | resolved | 0.85 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-pubmed-20260410- | Why does microglial HDAC1/2 deletion provide therapeutic benefit while neuroecto | open | 0.82 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-pubmed-20260410- | How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c | partially_addressed | 0.89 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-pubmed-20260410- | What molecular mechanisms explain why HDAC1/2 are essential for microglia develo | open | 0.83 | 0.00 | 2026-04-10 | 0 | | neuroinflammation |
| gap-debate-20260410- | How do smartphone-detected cognitive patterns correlate with specific neural net | open | 0.70 | 0.00 | 2026-04-10 | 0 | | digital-biomarkers |
| gap-debate-20260410- | What is the optimal timing window for motor cortex stimulation interventions? | open | 0.75 | 0.00 | 2026-04-10 | 0 | | neurostimulation |
| gap-debate-20260410- | Can retinal microvascular changes predict specific neurodegenerative pathways? | open | 0.85 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-debate-20260410- | Do circadian disruptions cause neurodegeneration or result from it? | partially_addressed | 0.90 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-debate-20260410- | Do mitochondrial-lysosome contact site defects precede or follow autophagy dysfu | open | 0.70 | 0.00 | 2026-04-10 | 0 | | cell-biology |
| gap-debate-20260410- | How can circadian autophagy rhythms be selectively restored without disrupting o | open | 0.80 | 0.00 | 2026-04-10 | 0 | | pharmacology |
| gap-debate-20260410- | Which specific temporal misalignments between protein aggregation and autophagy | open | 0.75 | 0.00 | 2026-04-10 | 0 | | chronobiology |
| gap-debate-20260410- | Is circadian disruption causal or consequential in neurodegeneration-associated | open | 0.85 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-debate-20260410- | Do APOE4's multiple pathological mechanisms require simultaneous targeting or is | open | 0.70 | 0.00 | 2026-04-10 | 0 | | molecular-biology |
| gap-debate-20260410- | Which specific lipid species have enhanced affinity for APOE4 conformation and c | open | 0.75 | 0.00 | 2026-04-10 | 0 | | biochemistry |
| gap-debate-20260410- | What are the druggable binding sites within the APOE4 interdomain interface? | resolved | 0.80 | 0.00 | 2026-04-10 | 0 | | structural-biology |
| gap-debate-20260410- | Does structural 'normalization' of APOE4 domain interactions actually improve am | partially_addressed | 0.90 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-debate-20260410- | How can specialized pro-resolving mediators be effectively delivered across the | open | 0.71 | 0.00 | 2026-04-10 | 0 | | drug-delivery |
| gap-debate-20260410- | Do compensation mechanisms upregulate alternative cytokine pathways when IL-1α i | open | 0.75 | 0.00 | 2026-04-10 | 0 | | immunology |
| gap-debate-20260410- | Can astrocyte-specific PFKFB3 inhibition selectively block complement production | open | 0.78 | 0.00 | 2026-04-10 | 0 | | neurobiology |
| gap-debate-20260410- | What is the optimal timing sequence for IL-1α blockade followed by complement re | open | 0.82 | 0.00 | 2026-04-10 | 0 | | neuroinflammation |
| gap-debate-20260410- | Do enhanced brain penetration strategies alter amyloid clearance kinetics suffic | open | 0.75 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-debate-20260410- | What are the structure-activity relationships for transferrin receptor binding a | open | 0.80 | 0.00 | 2026-04-10 | 0 | | protein-engineering |
| gap-debate-20260410- | How do efflux transporter compensatory mechanisms respond to chronic BBB penetra | resolved | 0.85 | 0.00 | 2026-04-10 | 0 | | pharmacokinetics |
| gap-debate-20260410- | What is the optimal BBB opening duration and spatial precision to maximize thera | partially_addressed | 0.90 | 0.00 | 2026-04-10 | 0 | | neuropharmacology |
| gap-pubmed-20260410- | Why do IDH1 and IDH2 mutations occur in mutually exclusive patterns in gliomas? | open | 0.80 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-pubmed-20260410- | What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity | partially_addressed | 0.89 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-pubmed-20260410- | How do brain cytoarchitectural changes detected by ADC imaging relate to functio | open | 0.77 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-pubmed-20260410- | What molecular mechanisms link MCT8 deficiency to specific astroglial alteration | open | 0.80 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-pubmed-20260410- | Why do MCTs1-4 require basigin/embigin for plasma membrane expression while MCT8 | open | 0.73 | 0.00 | 2026-04-10 | 0 | | neurometabolism |
| gap-pubmed-20260410- | What are the substrates and functional roles of the eight uncharacterized SLC16 | open | 0.80 | 0.00 | 2026-04-10 | 0 | | neurometabolism |
| gap-pubmed-20260410- | How do HCN1 channels contribute to photopic pathway processing beyond the establ | open | 0.78 | 0.00 | 2026-04-10 | 0 | | retinal-neurobiology |
| gap-pubmed-20260410- | What are the molecular mechanisms by which HCN1 channels shape rod photoresponse | open | 0.80 | 0.00 | 2026-04-10 | 0 | | retinal-neurobiology |
| gap-pubmed-20260410- | What determines whether HCN channel dysfunction causes cardiac versus neurologic | open | 0.70 | 0.00 | 2026-04-10 | 0 | | channelopathies |
| gap-pubmed-20260410- | How do different HCN isoforms (HCN1, HCN2, HCN4) contribute differentially to ep | open | 0.77 | 0.00 | 2026-04-10 | 0 | | neurological-disorders |
| gap-pubmed-20260410- | What are the specific mechanisms by which HCN channel alterations lead to neurod | resolved | 0.80 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-debate-20260410- | How do age-dependent baseline inflammatory states alter astrocyte reactivity swi | open | 0.73 | 0.00 | 2026-04-10 | 0 | | aging |
| gap-debate-20260410- | Do astrocytes exist in discrete A1/A2 subtypes or along a continuous activation | open | 0.85 | 0.00 | 2026-04-10 | 0 | | neurobiology |
| gap-debate-20260410- | What are the precise temporal kinetics required for sequential mTOR inhibition-a | open | 0.78 | 0.00 | 2026-04-10 | 0 | | neurodegeneration |
| gap-debate-20260410- | Can pharmacological approaches achieve controlled oscillatory modulation of Nrf2 | open | 0.82 | 0.00 | 2026-04-10 | 0 | | pharmacology |
| gap-debate-20260410- | What metabolic pathways coordinate energy demands with memory consolidation duri | open | 0.75 | 0.00 | 2026-04-10 | 0 | | metabolic-neuroscience |
| gap-debate-20260410- | Can transgenerational memory mechanisms be selectively targeted without broad ep | open | 0.85 | 0.00 | 2026-04-10 | 0 | | epigenetics |
| gap-debate-20260410- | Which specific brain regions and neural circuits mediate circadian-spatial memor | resolved | 0.80 | 0.00 | 2026-04-10 | 0 | | systems-neuroscience |
| gap-debate-20260410- | Do migratory animals encode specific spatial locations epigenetically or rely on | partially_addressed | 0.90 | 0.00 | 2026-04-10 | 0 | | behavioral-neuroscience |
| gap-debate-20260410- | How do CNS-penetrant properties affect JAK inhibitor efficacy in spinal cord ver | open | 0.70 | 0.00 | 2026-04-10 | 0 | | neuropharmacology |
| gap-debate-20260410- | Which complement activation pathway predominates in different myelopathy etiolog | open | 0.75 | 0.00 | 2026-04-10 | 0 | | immunology |
| gap-debate-20260410- | What is the temporal sequence of blood-spinal cord barrier breakdown relative to | open | 0.80 | 0.00 | 2026-04-10 | 0 | | neurovascular-biology |
| gap-debate-20260410- | Do microglia converge on a single activation state or maintain distinct profiles | open | 0.85 | 0.00 | 2026-04-10 | 0 | | neuroinflammation |
| gap-debate-20260410- | What are the cell-type specific effects of mTOR modulation in APOE4 carriers acr | open | 0.75 | 0.00 | 2026-04-10 | 0 | | neuropharmacology |