| h-var-e2b5a7e7db | GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance | 0.96 | 0.75 | GRIN2B | proposed | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-b7e4505525 | Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to | 0.96 | 0.78 | SST | promoted | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-e95d2d1d86 | Closed-loop optogenetic targeting PV interneurons to restore theta-gamma couplin | 0.95 | 0.78 | PVALB | promoted | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-SDA-2026-04-26-gap | Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables L | 0.94 | 0.33 | NEFL | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001521 |
| h-var-a4975bdd96 | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.91 | 0.78 | CCK | promoted | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-08a4d5c07a | Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration | 0.91 | 0.69 | NLRP3, CASP1, IL1B, PYCARD | proposed | 2026-04-05 | SDA-2026-04-01-gap-20260401-225149 |
| h-bdbd2120 | Gamma entrainment therapy to restore hippocampal-cortical synchrony | 0.90 | 0.82 | SST | promoted | 2026-04-02 | SDA-2026-04-03-26abc5e5f9f2 |
| h-b2ebc9b2 | Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse | 0.89 | 0.58 | SLC16A1, SLC16A7, LDHA, PDHA1 | promoted | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-170057-a2f72fd8 |
| h-var-b7de826706 | SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence | 0.89 | 0.78 | SIRT1 | proposed | 2026-04-12 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-66156774e7 | TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration | 0.89 | 0.75 | TREM2 | superseded | 2026-04-07 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| hyp-SDA-2026-04-12-2 | Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible | 0.89 | 0.75 | APP/PSEN1 (Aβ production), CHAT (cholinergic synthesis) | debated | 2026-04-13 | SDA-2026-04-12-20260411-082446-2c1c9e2d |
| h-f1c67177 | Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M | 0.89 | 0.55 | IFNG | promoted | 2026-04-17 | SDA-2026-04-16-gap-debate-20260410-112642-fffdca96 |
| h-5b378bd3 | TREM2-APOE Axis Dissociation for Selective DAM Activation | 0.89 | 0.65 | TREM2-APOE axis | proposed | 2026-04-17 | SDA-2026-04-01-gap-001 |
| h-ccc05373 | p38α Inhibitor and PRMT1 Activator Combination to Restore Physiological TDP-43 P | 0.88 | 0.72 | MAPK14/PRMT1 | promoted | 2026-04-13 | SDA-2026-04-12-gap-debate-20260410-113051-5dce7651 |
| h-51e7234f | APOE-Dependent Autophagy Restoration | 0.88 | 0.75 | MTOR | promoted | 2026-04-03 | SDA-BIOMNI-SURVIVAL-3e217f4d |
| h-var-9c0368bb70 | Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stab | 0.87 | 0.76 | BDNF | promoted | 2026-04-05 | SDA-2026-04-03-26abc5e5f9f2 |
| h-seaad-v4-26ba859b | ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia | 0.87 | 0.78 | ACSL4 | promoted | 2026-04-03 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-e64a33a8 | Complement Cascade Inhibition Synaptic Protection | 0.87 | 0.52 | | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150544-e3a2eab9 |
| h-alsmnd-870c6115d68 | eIF2α Phosphorylation Imbalance Creates Integrated Stress Response Overflow That | 0.87 | 0.75 | EIF2S1,eIF2α,PERK,GCN2,ATF4,ATF5,CHOP,DDIT3,integrated stres | open | 2026-04-28 | |
| h-var-6c90f2e594 | Optogenetic restoration of hippocampal gamma oscillations via selective PV inter | 0.87 | 0.72 | PVALB | promoted | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-7b7ab657 | Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV | 0.87 | 0.50 | PVALB, CREB1, lncRNA-9969, neuronal autophagy pathway | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150509-76c40dac |
| h-var-95b0f9a6bc | Glymphatic-Mediated Tau Clearance Dysfunction | 0.86 | 0.72 | MAPT | promoted | 2026-04-07 | SDA-BIOMNI-PROTEOMI-c4a33049 |
| h-var-862d6a66d2 | Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta- | 0.86 | 0.65 | PVALB | proposed | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-881bc290 | TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Faile | 0.86 | 0.60 | NAMPT | proposed | 2026-04-17 | SDA-BIOMNI-VARIANT_-b5b8e32f |
| h-var-7c976d9fb7 | TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance | 0.86 | 0.84 | TREM2 | proposed | 2026-04-12 | SDA-2026-04-26-trem2-showcase |
| h-9e9fee95 | Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation | 0.86 | 0.80 | HCRTR1/HCRTR2 | promoted | 2026-04-02 | sda-2026-04-01-gap-v2-ee5a5023 |
| h-alsmnd-9d62ae58bdc | RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA Processing Condensate | 0.86 | 0.75 | RBM45,GSK3B,TDP-43,TARDBP,hnRNP A1,HNRNPA1,phase separation, | open | 2026-04-28 | |
| h-fc1cd0d4bd | H6: Aberrant eIF2α Phosphorylation Creates Stalled Translation State | 0.86 | 0.80 | EIF2S1, EIF2AK3/PERK, PPP1R15B, EIF2B | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad |
| h-var-76afa28dfc | Senescent Cell ASM-Complement Cascade Intervention | 0.85 | 0.72 | SMPD1 | promoted | 2026-04-07 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-alsmnd-c5d2e9c2ede | SFPQ Paralog Displacement Triggers Cryptic Polyadenylation and Global RNA Stabil | 0.85 | 0.75 | SFPQ,NONO,PSP1,TARDBP,poly(A) machinery,CPSF,PABPN1 | open | 2026-04-28 | |
| h-SDA-2026-04-26-gap | Elevated CSF/Serum Albumin Quotient Predicts Neurodegeneration Progression Indep | 0.85 | 0.46 | ALB | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001521 |
| h-var-4eca108177 | Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth | 0.85 | 0.81 | PVALB | promoted | 2026-04-05 | SDA-2026-04-03-26abc5e5f9f2 |
| h-31ca9240f9fc | TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling AL | 0.85 | 0.82 | TBK1 → NF-κB / IRF3 / p62-autophagy / cGAS-STING axis | debated | 2026-04-26 | SDA-2026-04-26-gap-20260425215446 |
| h-var-e47f17ca3b | Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f | 0.85 | 0.80 | SST | promoted | 2026-04-05 | SDA-2026-04-03-26abc5e5f9f2 |
| h-f503b337 | TYROBP (DAP12) Conditional Antagonism for Early-Stage Neuroprotection | 0.84 | 0.58 | TYROBP | proposed | 2026-04-17 | SDA-BIOMNI-GENE_COE-55fc5237 |
| h-var-e81fbd3868 | Neutral Sphingomyelinase-2 Inhibition for Synaptic Protection in Neurodegenerati | 0.84 | 0.72 | SMPD3 | promoted | 2026-04-07 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-740803e1 | miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Prot | 0.84 | 0.65 | MIR155 | proposed | 2026-04-17 | SDA-2026-04-16-gap-debate-20260410-112642-fffdca96 |
| h-alsmnd-9d07702213f | ATM Kinase Hyperactivation Triggers DNA Damage Response Overflow and p53-Depende | 0.84 | 0.75 | ATM,CHEK2,TP53,BAX,PUMA,BCL2,DNA damage response,oxidative s | open | 2026-04-28 | |
| h-3481330a | Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte Secretome | 0.84 | 0.65 | SST, SSTR1, SSTR2 | promoted | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-170057-a2f72fd8 |
| h-5050522d | Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Pre | 0.84 | 0.58 | Labile iron pool (deferoxamine target) and GPX4 (sulforaphan | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-174000-6451afef |
| h-c226f2aa | Gamma Oscillation Enhancement Synergy | 0.84 | 0.42 | | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150544-e3a2eab9 |
| h-d5dea85f | Microglial Senescence Prevention via TREM2/SASP Axis | 0.84 | 0.48 | TREM2 | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150544-e3a2eab9 |
| h-alsmnd-006d646506a | hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Transport Failure Drives Distal | 0.83 | 0.75 | HNRNPA2B1,STAU2,PRMT1,GSK3B,MAP1B,β-actin,axonal transport m | open | 2026-04-28 | |
| h-2dbf5f1f | IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interface | 0.83 | 0.78 | IL6R, IL6 | promoted | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-150500-e110aab9 |
| h-2f3fa14b | Ketone Utilization Index as Metabolic Flexibility Biomarker | 0.83 | 0.40 | HMGCS2 | proposed | 2026-04-17 | SDA-2026-04-04-gap-debate-20260403-222618-c698b06a |
| h-44b1c9d415 | TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's D | 0.83 | 0.88 | TREM2 | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| h-var-ce41f0efd7 | Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling | 0.83 | 0.75 | TREM2 | promoted | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-9e8fc8fd3d | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.83 | 0.45 | PVALB | promoted | 2026-04-16 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-d33964b962 | Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter | 0.83 | 0.45 | SST | proposed | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-42f50a4a | Prime Editing Precision Correction of APOE4 to APOE3 in Microglia | 0.83 | 0.70 | APOE | promoted | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |