| h-4fabd9ce | Cryptic Exon Silencing Restoration | 0.53 | 0.70 | TARDBP | debated | 2026-04-02 | sda-2026-04-01-gap-v2-68d9c9c1 |
| h-0ba5108157 | Oligodendrocyte Lineage Vulnerability: Early Myelination Disruption with Blocked | 0.53 | 0.55 | PDGFRα | proposed | 2026-04-22 | SDA-2026-04-02-gap-seaad-debate-v4 |
| h-c381434159 | CX3CR1-Targeted AntimiR-155 Oligonucleotides for Microglial Priming Reversal | 0.53 | 0.58 | MIR155 (microRNA-155) | proposed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf |
| h-5c9b3fe9 | Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes | 0.53 | 0.55 | Polycomb-to-Trithorax Switch at | proposed | 2026-04-25 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| h-851ef04ad8 | Dendritic tau missorting persists through local proteostatic failure in endolyso | 0.53 | 0.56 | MAPT,RAB5,RAB7,LAMP1,TFEB | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-98a600b3ed |
| h-d083850487 | TREM2-dependent microglial phagocytosis of tau seeds | 0.53 | 0.50 | TREM2/Syk/PLCγ2 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| h-56a149a41c | NAC + Ferrostatin-1 Combination for Peroxynitrite-Ferroptosis Crosstalk | 0.53 | 0.62 | Convergent: GSH depletion + peroxynitrite + lipid radical ac | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| h-c98d1cb4e7 | AAV-mediated RGS6 re-expression in SNpc after pathology onset | 0.53 | 0.42 | RGS6 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-145520-5692b02e-debate |
| h-metrep-623b0389f6c | CyclinD1-Tagged Partial Cellular Reprogramming via Modified Yamanaka Cocktail Re | 0.53 | 0.75 | OCT4,POU5F1,SOX2,KLF4,MYC,CCND1,CDKN2A,CDKN1A,MAP2,NEUN,SYN1 | proposed | 2026-04-28 | |
| h-428057939b | Modulating Tunneling Nanotube (TNT) Formation via M-Sec/Noradrenaline Signaling | 0.53 | 0.48 | TNFRSF12A (M-Sec) | proposed | 2026-04-22 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-658167b004 | GDNF-RET Trophic Signaling Deficit | 0.53 | 0.50 | GDNF; RET; VCP | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |
| h-ebf902e71c | PI3P Generation at Damaged Lysosomes Promotes Membrane Repair | 0.53 | 0.48 | PIK3C3/VPS34, CHMP2A | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-a6cc7467 |
| h-2842eb0a8b | C1q shows synapse-class-specific roles, with inhibitory versus excitatory synaps | 0.53 | 0.52 | C1QA,C1QB,C1QC,GAD1,GAD2,SLC6A1,SLC17A7,ITGAM,ITGB2 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-afba1a80bd |
| h-26d64f6a47 | Therapeutic Repurposing: C1-INH as Plaque-Stabilizing Agent | 0.53 | 0.52 | C1R/C1S | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-df18198e59 | ER-mitochondria contact-site dysfunction in neurodegeneration | 0.53 | 0.56 | MFN2; ITPR1; HSPA9; VDAC1 | proposed | 2026-04-30 | SDA-2026-04-30-gap-test-20260425-224949 |
| h-fcd35131cf | C1Q-Angiogenic Axis Promoting Plaque Neovascularization | 0.53 | 0.55 | C1QA/C1QC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-e9c2d00456 | H4: Polycomb Repression Relaxes at Neurodevelopment Genes | 0.53 | 0.61 | EZH2, H3K27me3, CBX proteins | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-120802 |
| h-analogy-2be480e6 | Closed-loop neuromodulation-inspired cytokine axis suppression to restore Cx43 h | 0.53 | 0.35 | GJA1 (Cx43) | active | 2026-04-28 | |
| h-5ff6c5ca | Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioenergetics | 0.53 | 0.30 | SLC16A2 | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-2a4e4ad2 | PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor Mitochondria | 0.53 | 0.50 | BNIP3/BNIP3L | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401231108 |
| h-115a27fb8c | DNMT1 Compensation Window During Synaptic Resilience Phase | 0.53 | 0.60 | DNMT1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b |
| h-37fc3b23a5 | Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA | 0.53 | 0.50 | IGFBPL1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-8520098f4d | Neurodevelopmental Sex Differences in Thalamocortical GluN2B-Glymphatic Coupling | 0.53 | 0.48 | Developmental GRIN2B expression timing; AQP4 astrocyte matur | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e2b5a7e7db |
| h-5137be61 | Neuronal Integrated Stress Response Modulation | 0.53 | 0.60 | EIF2AK3 (PERK) and EIF2B complex | proposed | 2026-04-04 | SDA-2026-04-03-gap-seaad-v2-20260402032945 |
| h-5626c1f2 | Temporal Metabolic Window Therapy | 0.53 | 0.70 | HMGCS2 | promoted | 2026-04-12 | SDA-2026-04-04-gap-debate-20260403-222618-e6a431dd |
| h-64e3588957 | TREM2 Epigenetic Window for Microglial Lipid Metabolism | 0.53 | 0.55 | TREM2/HDAC1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b |
| h-910e7283b7 | Epigenetic CRISPR/dCas9 Activation of PV Gene Program Prevents Aβ-Induced Transc | 0.53 | 0.50 | DNMT3A/PVALB promoter | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| h-332083afc1 | Sleep-Stage TFUS to Restore SWR-Gamma Coupling and Memory Consolidation | 0.53 | 0.40 | CB1 (CNR1), HCN1, Kv3.1 (KCNC1) | proposed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| h-c7350d53bb | Gut-derived butyrate reprograms microglia for amyloid clearance via HDAC2 inhibi | 0.53 | 0.72 | HDAC2 | proposed | 2026-04-26 | sda-2026-04-01-003 |
| h-2b545285ee | Glucosylceramide accumulation nucleates alpha-synuclein aggregation via lipid ra | 0.53 | 0.72 | GBA | proposed | 2026-04-26 | sda-2026-04-01-002 |
| h-1e2b7f1c | VPS35 Retromer Restoration to Rescue Endosomal Protein Trafficking | 0.52 | 0.53 | VPS35 (VPS26/VPS29/VPS35 complex) | proposed | 2026-04-25 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-0aecd2de | Pharmacogenomic CNS Drug Optimization Platform | 0.52 | 0.80 | CYP450 enzymes, transporters, and drug targets | promoted | 2026-04-12 | SDA-2026-04-04-gap-debate-20260403-222549-20260402 |
| h-c32ed9ee29 | Microglial Reactivation Status Modifies Amyloid Clearance and p-tau217 Normaliza | 0.52 | 0.45 | TREM2 | proposed | 2026-04-25 | |
| h-var-31dc5b3ecb | TREM2-Dependent Microglial Control of Thalamocortical-Glymphatic Tau Clearance | 0.52 | 0.67 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-03-26abc5e5f9f2 |
| h-50ee9ed1ea | Circadian Clock Epigenetic Desynchronization Window | 0.52 | 0.52 | BMAL1/HDAC3 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b |
| h-var-cf5d8c96cb | TFEB Activation to Restore Lysosomal Biogenesis in Alzheimer's Disease Neuronal | 0.52 | 0.26 | TFEB | proposed | 2026-04-26 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-23b49dc7d3 | Charge-Pattern Asymmetry Creates Electrostatic Recruitment Gates | 0.52 | 0.58 | 53BP1/TP53BP1 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075026-23501c3c |
| h-2ae232e9fa | C1q Binding to Specific Synaptic Proteomes via Neurexin/Neuroligin Complexes | 0.52 | 0.55 | NRXN1, NLGN1 (Neuroligin 1) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| h-985b8091 | TREM2 Agonism to Redirect Microglia from Synaptic Pruning to OPTN-Deficient Neur | 0.52 | 0.52 | TREM2 | proposed | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-183548-043c7918 |
| h-2ef151e6f1 | Severely Depleted mtDNA and Impaired OXPHOS Defines Senescent Microglia | 0.52 | 0.58 | MT-ND1, MT-CO1, TFAM, SIRT3 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-d0c592780a | Gamma/tFUS Entrainment as Biomarker Modulator of Neuroinflammation, Amyloid, and | 0.52 | 0.55 | APOE, TREM2 (exploratory only); NF-κB, TNF-α, IL-1β, IL-6 | proposed | 2026-04-28 | SRB-2026-04-28-h-var-b7e4505525 |
| h-0c6d0bb791 | Telomere Attrition and DNA Damage Response Activation Induces Microglial Senesce | 0.52 | 0.58 | TP53/CDKN2A/CDKN1A/ATM/ATR | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-f70d50d17e | Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence | 0.52 | 0.55 | CGAS/STING1/TMEM173 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-6c20b3450d | HDAC1/2 Complex Restoration Corrects Age-Related Histone Hypoacetylation | 0.52 | 0.55 | HDAC1; HDAC2 | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-579343d94c | Restoring AQP4 Astrocyte Polarization Enhances Glymphatic Tau Clearance and Limi | 0.52 | 0.52 | AQP4 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-04780f23 | Neuronal Hypersensitivity to Feedback Inhibition by p62/Sequestosome-1 Accumulat | 0.52 | 0.50 | SQSTM1 (p62), mTORC1, TRAF6 | proposed | 2026-04-26 | SDA-2026-04-07-gap-pubmed-20260406-062212-ca78691c |
| h-bfbc071096 | Perineuronal Net Depolymerization as Early Synaptic Vulnerability Trigger | 0.52 | 0.55 | CSPG, MMP-9, aggrecan | proposed | 2026-05-03 | SDA-2026-05-03-gap-test-20260425-224949 |
| h-d93e5da83c | AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal Epigenetic Age Witho | 0.52 | 0.58 | OCT4/SOX2/KLF4 (OSK)/Epigenetic clock | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-060512 |
| h-2d5e4bc423 | HBOT at 2.0 ATA for 60 minutes restores PGC-1α-mediated mitochondrial biogenesis | 0.52 | 0.55 | PPARGC1A (PGC-1α) | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-181340-8acb24dc-debate |
| h-b701c493b0 | Dysregulated microglial glycolysis via HIF1α activation shifts the balance from | 0.52 | 0.58 | HIF1A, LDHA, LDHB, PKM2, TREM2, AMPK/mTOR | proposed | 2026-04-22 | SDA-2026-04-02-gap-synaptic-pruning-microglia |