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Ranked Hypotheses

1,388 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
9f06a8cc-c784-4260-8APOE ε4 Drives Lipid Droplet Accumulation in a Unique Lipid-Associated Microglia0.700.65APOEopen2026-04-278f05a068-5b1e-4f32-8ca9-2f375b5dbaf3
h-76888762Perforant Path Presynaptic Terminal Protection Strategy0.700.50PPARGC1Adebated2026-04-02sda-2026-04-01-gap-004
h-8196b893Axonal RNA Transport Reconstitution0.700.70HNRNPA2B1debated2026-04-02sda-2026-04-01-gap-v2-68d9c9c1
h-969bd8e0Mitochondrial Transfer Pathway Enhancement0.700.30MIRO1debated2026-04-02sda-2026-04-01-gap-007
h-21cd4ba1Temporal Microglial State Switching0.700.56Optogenetic constructs, ion channelsproposed2026-04-04SDA-2026-04-04-gap-neuroinflammation-microglial-20260404
h-1fe4ba9bComplement C1q Mimetic Decoy Therapy0.690.68C1QAdebated2026-04-02sda-2026-04-01-gap-v2-691b42f1
h-ac55ff26Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Therapy0.690.40ALOX15debated2026-04-02sda-2026-04-01-gap-014
h-bf7edcbc78APOE4 hypolipidation and ABCA1 mistrafficking impair cholesterol efflux and seco0.690.68ABCA1proposed2026-04-24SDA-2026-04-25-gapdebate-f4c8357045
h-7de0b0cd41c1Endosomal escape determines whether transferred tau becomes pathogenic0.690.67RAB7Aproposed2026-04-26SDA-2026-04-26-gap-debate-20260412-094623-bb7e1c4f
h-441b25baPalmitoylation-Targeted BACE1 Trafficking Disruptors0.690.60BACE1proposed2026-04-02SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-afb4b745b7Drp1-S616 Phosphorylation Fission Priming Enables t-Bid-Driven MPTP Amplificatio0.690.68DRP1 (DNM1L), BIDproposed2026-04-21SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c
h-6a065252Ocular Immune Privilege Extension0.690.20FOXP3/TGFB1debated2026-04-02sda-2026-04-01-gap-012
h-fdb07848Sphingomyelin Synthase Activators for Raft Remodeling0.690.70SGMS1/SGMS2promoted2026-04-02SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-bbe4540fcGAS-STING Senescence Circuit Disruption0.690.80CGAS, STING1promoted2026-04-04SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-725c62e9Extracellular Matrix Stiffness Modulation0.690.50PIEZO1debated2026-04-02sda-2026-04-01-gap-009
h-bf2e53d730TDP-43 phase-separation and nuclear-function failure in ALS/FTD0.690.78TARDBP; TIA1proposed2026-04-30SDA-2026-04-30-gap-test-20260425-224949
h-556fe28ea9Astrocyte Reactivity Heterogeneity with APOE4-Dependent Vulnerability0.690.65APOEproposed2026-04-22SDA-2026-04-02-gap-seaad-debate-v4
h-28f5f4a34bComplement C1q/C3 Inhibition to Prevent Synaptodendritis in Alzheimer's Disease0.690.78C1Q/C3proposed2026-04-28SDA-2026-04-28-gap-test-20260425-224949
hyp-lyso-snca-f7d4ffSNCA Aggregation Hijacks the Endosomal Sorting Complex Required for Transport (E0.690.72SNCAactive2026-04-27
h-c7f5c90ab1TREM2-Dependent Microglial State Transition as Therapeutic Window in Alzheimer's0.690.78TREM2, SYK signaling pathwayproposed2026-04-22SDA-2026-04-02-gap-2026-04-01-gap-006
h-9a862b0e02TFEB-Dependent Lysosome Biogenesis0.690.68TFEB/TFE3proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062150-a6cc7467
h-2a9928e512Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex pr0.690.66RAB27Aproposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062052-946439a8
h-a17f8f1de6TREM2 Agonism to Rescue APOE4-Induced Microglial Dysfunction0.690.70TREM2proposed2026-04-22SDA-2026-04-02-gap-apoe4-targeting
h-ebefda890eLoss of AQP4 Polarization Impairs Glymphatic Perivascular Influx, Causing Metabo0.690.78AQP4proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e
h-f3751a9ee4Time-Limited AQP4 Inhibition for Acute Cytotoxic Edema Followed by Therapeutic R0.690.68AQP4proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2
h-ae63a5a13cH5: BET Bromodomain Readers Sense Aberrant Chromatin and Drive Neuroinflammatory0.690.75BRD4, BET bromodomains (BRD2/3/4)proposed2026-04-22SDA-2026-04-04-gap-20260404-120802
h-4814bca81eAstrocyte-Neuron Metabolic Coupling Failure Precedes Neurodegeneration in FTD-GR0.690.71GRN, SLC16A3 (MCT4)proposed2026-04-22SDA-2026-04-02-gap-2026-04-01-gap-006
h-fa83846f7dMicroglia and complement sustain post-Aβ neurodegeneration after tau missorting 0.690.76C1QA,C1QB,C1QC,C3,ITGAM,TREM2,TYROBPproposed2026-04-25SDA-2026-04-25-gapdebate-98a600b3ed
h-12599989Ganglioside Rebalancing Therapy0.690.65ST3GAL2/ST8SIA1proposed2026-04-02SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-b490c14bf6CSF Soluble TREM2 Fragment Ratio as Priming State Indicator0.690.58TREM2/ADAM10/17proposed2026-04-22SDA-2026-04-06-gap-debate-20260406-062039-3b945972
h-69461336Endothelial NRF2 Activation as a Master Switch for Post-CA BBB Protection0.690.49NRF2 (NFE2L2) in brain microvascular endothelial cellspromoted2026-04-17SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate
h-d2df6eafReelin-Mediated Cytoskeletal Stabilization Protocol0.690.50RELNdebated2026-04-02sda-2026-04-01-gap-004
h-eea667a9Cross-Seeding Prevention Strategy0.690.68TARDBPdebated2026-04-02sda-2026-04-01-gap-v2-68d9c9c1
h-6b84d8e2Hypocretin-Neurogenesis Coupling Therapy0.690.30HCRTdebated2026-04-02sda-2026-04-01-gap-v2-18cf98ca
h-b295a9ddLysosomal Positioning Dynamics Modulation0.690.58LAMP1debated2026-04-02sda-2026-04-01-gap-011
h-a54ec316Wnt/β-catenin Pathway Restoration0.690.72CTNNB1proposed2026-04-16SDA-2026-04-16-gap-bbb-tjp-20260416041707
h-044ee057TREM2 Conformational Stabilizers for Synaptic Discrimination0.690.50TREM2debated2026-04-02sda-2026-04-01-gap-v2-691b42f1
h-6ed7b5c8TREM2-APOE Axis Manipulation via APOE Lipidation for DAM Recruitment0.690.78TREM2-APOEproposed2026-04-25SDA-2026-04-17-gap-microglial-subtypes-pharmaco-202604170000
h-SDA-2026-04-26-gapPlasma D-Dimer Elevation Reflects Fibrinogen Leakage and Secondary Fibrinolysis 0.690.44FGA, FGB, FGG, D-dimerproposed2026-04-26SDA-2026-04-26-gap-20260426-002803
h-SDA-2026-04-26-gapBlood Astrocyte-Derived Exosomal AQP4 Mislocalization Predicts Early Glymphatic 0.690.44AQP4proposed2026-04-26SDA-2026-04-26-gap-20260426-002803
h-31980740GLUT1-Mediated Glucose Flux Coefficient as Neuroprotection Indicator0.680.60SLC2A1proposed2026-04-16SDA-2026-04-04-gap-debate-20260403-222618-c698b06a
h-73e4340bPericyte Contractility Reset via Selective PDGFR-β Agonism0.680.45PDGFRBdebated2026-04-02sda-2026-04-01-gap-v2-ee5a5023
h-37d2482dhnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for 0.680.30hnRNPA2B1, lncRNA-0021 (RBP-bound state)proposed2026-04-17SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate
h-21d655104eFocused Ultrasound with Microbubble Contrast Agents0.680.70IGFBPL1proposed2026-04-22SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf
h-analogy-8b267076ISR/eIF2α~P Overflow Represses Synaptic Protein Synthesis Downstream of Tau/Aβ P0.680.65EIF2AK3 (PERK)active2026-04-28
h-analogy-aadfdd67FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensate Hijacking of RNA 0.680.65FUSactive2026-04-28
h-2698e999Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During Develop0.680.82SYNGAP1promoted2026-04-15SDA-2026-04-15-gap-pubmed-20260411-084510-fbfafe2c
h-2ca830cdSTMN2 Restoration as a Prerequisite for Axon Growth After TDP-43 Clearance0.680.78STMN2promoted2026-04-14SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917
h-2651ca91Multi-Target Synergy via Presynaptic Vesicle Hub Convergence0.680.42TH, VMAT2, DAT, GCH1, BDNF, SNCA (presynaptic hub)proposed2026-04-13SDA-2026-04-13-gap-pubmed-20260410-145531-5c4e7b59
h-541d61c3Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles0.680.80APOE4promoted2026-04-04SDA-2026-04-03-gap-debate-20260403-222543-20260402
7891011
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