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🎯 Drug Targets

Browse 5 drug targets with druggability analysis, composite scores, and clinical context

5
Targets
0
High Druggability
0.62
Avg Score
15
Target Classes
Druggability Distribution
High: 0Medium: 0Low: 5Unknown: 0
Avg druggability score: 0.391
Clinical Pipeline
Approved: 1Phase III: 0Phase II: 1Phase I: 3Preclinical: 0
Total compounds: 7 · Approved: 0
Class All Classes Enzyme (35) Signaling Protein (25) Structural Protein (17) Protein (16) Gpcr (13) Ion Channel (12) Transcription Factor (11) Receptor (11) Ligand (10) Transporter (8) Epigenetic Regulator (8) Kinase (7) Protease (4) Other (4) Chaperone (4)
Druggability All Druggability Low (100) Medium (62) High (14) Undruggable (6) other (3)
Sort Score Druggability Gene A-Z Market Price
Filtered by: class=epigenetic_regulator, druggability=Low — 5 results
HDAC3 Histone Deacetylase 3 Phase 4
Epigenetic Regulator Low Druggability
Score
0.66
Drug.
0.41
Safety
0.40
Drugs
2
Hyps
5
Papers
36
Small molecule inhibitor of histone deacetylase enzymatic activity
SIRT6 Sirtuin-6 Phase 1
Epigenetic Regulator Low Druggability
Score
0.65
Drug.
0.41
Safety
0.60
Drugs
1
Hyps
2
Papers
36
Small molecule activation or inhibition of NAD+-dependent deacetylase activity
TET2 Tet methylcytosine dioxygenase 2 Phase 2
Epigenetic Regulator Low Druggability
Score
0.61
Drug.
0.42
Safety
0.60
Drugs
2
Hyps
6
Papers
65
Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation
PRMT1 Protein arginine methyltransferase 1 Phase 1
Epigenetic Regulator Low Druggability
Score
0.61
Drug.
0.36
Safety
0.50
Drugs
1
Hyps
1
Papers
32
Small molecule inhibitor of protein arginine methyltransferase activity
KDM6A Lysine demethylase 6A Phase 1
Epigenetic Regulator Low Druggability
Score
0.59
Drug.
0.35
Safety
0.40
Drugs
1
Hyps
1
Papers
36
Small molecule inhibition of histone demethylase activity
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