Druggability & Clinical Context
Druggability
High
Score: 0.73
Clinical Stage
Preclinical
Target Class
Epigenetic Regulator
Druggability Analysis
Structural Tractability0.70
Key Metrics
PDB Structures:
5
Known Drugs:
2
Approved:
0
In Clinical Trials:
0
Drug Pipeline (2 compounds)
Therapeutic Areas:Neuroinflammation Neurodegeneration Epigenetics
Mechanism: BRD4 inhibition reduces neuroinflammatory super-enhancer activity while biased BRD4 modulators can selectively restore neuroprotective gene expression
Drug Pipeline (2 compounds)
Known Drugs:JQ1 (Preclinical (tool compound))
OTX015 (Clinical (oncology))
Structural Data:PDB (5) ✓AlphaFold ✓Cryo-EM —