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gene 1,784 words KG: AIM2
Contents

AIM2 Gene

🧬 Gene Info
Gene SymbolAIM2
Protein FamilyAIM2-like receptor (ALR)
FunctionAIM2 functions as a cytosolic DNA sensor forming the AIM2 inflammasome.
Subcellular LocalizationCytoplasm
Molecular Weight39 kDa
Amino Acids200 aa
PathwaysApoptosis, Autophagy, Cholesterol, Ferroptosis, Immune Response
UniProt IDQ9WZE6
GeneCardsAIM2
Human Protein AtlasAIM2
Associated DiseasesAls, Atherosclerosis, Cancer, Dementia, Infection
InteractionsACTB, Actin, ALZHEIMER, AMPK, AND, APOPTOSIS
KG Connections410 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.82Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N
Score: 0.81Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re
Score: 0.80Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu
Score: 0.80

Knowledge Graph (12 edges)

IL1B associated_with AIM2
CASP1 associated_with AIM2
ATG5 associated_with AIM2
NLRC4 associated_with AIM2
ASC associated_with AIM2
NLRP3 associated_with AIM2
AIM2 associated_with TNF
AIM2 associated_with MARCH7
AIM2 associated_with PYCARD
AIM2 associated_with LAMP1

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