| Gene Symbol | ent-gene-bf93c073 |
| Target Site | Therapeutic Approach |
| AIM2 DNA binding (HIN domain) | Direct inhibitors blocking DNA binding |
| AIM2 oligomerization | Oligomerization inhibitors |
| AIM2-ASC interaction | Pyrin domain antagonists |
| Caspase-1 | Approved inhibitors (e.g., VX-765) |
| IL-1β signaling | Anakinra, Canakinumab |
| Gasdermin D | GSDMD inhibitors |
| Compound | Target |
| AIM2-HIN antagonist | Blocks DNA binding to HIN domain |
| AIM2 oligomerization inhibitor | Prevents AIM2 assembly |
| Pyrin domain inhibitor | Blocks ASC interaction |
| VX-765 (Belnacasan) | Caspase-1 |
| Mcc950 | NLRP3 |
| Dapansutrile (OLT1177) | NLRP3 |
| Drug | Original Indication |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |