| Major causal genes | C9orf72, SOD1, FUS, TARDBP (accounting for ~70% of familial ALS) |
| Moderate risk genes | UBQLN2, OPTN, TBK1, VCP, ANG |
| GWAS-identified loci | Over 15 risk loci identified through genome-wide studies |
| Databases | OMIMOrphanetClinicalTrialsPubMed |