| Gene Symbol | ent-gene-ec734edb |
| N-terminal domain (ATD) | extracellular agonist-binding domain involved in subunit assembly and allosteric modulation |
| Ligand-binding domain (LBD) | twoushiell domains (S1 and S2) that bind glutamate and kainate |
| Transmembrane domain (TMD) | three membrane-spanning helices (M1-M3) forming the ion channel pore |
| C-terminal domain (CTD) | intracellular region involved in protein interactions and trafficking |
| CA3 region | Highest density of GluK2-containing KARs, particularly on mossy fiber terminals |
| CA1 stratum radiatum | Modulates Schaffer collateral-CA1 synaptic transmission |
| Dentate gyrus | Regulates granule cell excitability and pattern separation |
| Purkinje cells | GluK2 contributes to cerebellar motor learning and coordination |
| Granule cells | Express GluK2 as part of heteromeric receptors |
| Molecular layer | Modulates parallel fiber-Purkinje cell signaling |
| Layer II/III pyramidal neurons | Express GluK2 in cortical microcircuits |
| Interneurons | Various GABAergic populations express GluK2 |
| Temporal cortex | High expression in regions relevant to memory and AD pathology |
| Amygdala | Modulates fear conditioning and emotional memory |
| Thalamus | Sensory relay nuclei contain GluK2-expressing neurons |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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