| Gene Symbol | ent-gene-51f4e611 |
| N-terminal domain (NTD) | Large extracellular domain involved in subunit assembly and allosteric modulation |
| Agonist-binding domain (ABD) | Binds glutamate (on NR2A) and glycine/D-serine (on NR1) |
| Transmembrane domain (TM) | Three transmembrane helices plus a re-entrant pore loop |
| C-terminal domain (CTD) | Long intracellular tail that interacts with scaffolding proteins and signaling molecules |
| Two NR1 subunits | The obligatory glycine/D-serine binding subunit |
| Fast deactivation kinetics | NR2A-containing receptors have faster decay times than NR2B-containing receptors |
| Higher open probability | More likely to conduct ions when activated |
| Calcium permeability | Highly calcium-permeable, driving downstream signaling |
| Synaptic targeting | NR2A is preferentially targeted to synaptic sites |
| Cerebral cortex | All layers, particularly layer 2/3 and layer 5 pyramidal neurons |
| Hippocampus | CA1, CA2, and CA3 pyramidal neurons; dentate gyrus granule cells; interneurons |
| Striatum | Medium spiny neurons, cholinergic interneurons, GABAergic interneurons |
| Thalamus | Relay neurons, interneurons |
| Cerebellum | Purkinje cells, granule cells |
| Amygdala | Principal neurons, interneurons |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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