| Gene Symbol | PRKN |
| Full Name | Parkin RBR E3 Ubiquitin Protein Ligase |
| Chromosome | 6q26 |
| Protein Type | Ligase |
| Function | is a gene located on chromosome 6q26 that encodes an E3 ubiquitin ligase essential for mitochondrial quality control and mitophagy[@kitada1998]. |
| Primary Expression | Substantia nigra, Striatum, Cortex, Heart, Skeletal muscle |
| Pathways | Autophagy, E3 Ligase Activity, Glycolysis, Mitophagy, Oxidative Stress |
| UniProt ID | O60260 |
| NCBI Gene ID | 5071 |
| Ensembl ID | ENSG00000185348 |
| OMIM | 602544 |
| GeneCards | PRKN |
| Human Protein Atlas | PRKN |
| Process | Role |
| Mitophagy | Tags damaged mitochondria for autophagic clearance |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Known Drugs/Compounds | Fumarate, FB231, nicotinamide, dimethyl fumarate, rapamycin |
| Interactions | BCL2L11, MUL1, BNIP3, DISC1, EIF2S1, RIPK3 |
| KG Connections | 1684 knowledge graph edges |
| Databases | GeneCardsHPASTRING |