cell 886 words KG: ent-gene-4ec3184d 2026-03-22
kind:cell-typesection:cell-typesstate:published
Contents

PNMT Phenylethanolamine N-methyltransferase Neurons

🔬 Protein Info
Gene Symbolent-gene-4ec3184d
CategoryAdrenergic neurons
LocationAdrenal medulla, brainstem (C1-C3 groups)
Key EnzymePhenylethanolamine N-methyltransferase (PNMT)
Primary TransmitterEpinephrine
Secondary TransmitterNorepinephrine
Receptor TargetsAlpha1, alpha2, beta1, beta2 adrenergic receptors
EnzymeAbbreviation
Tyrosine HydroxylaseTH
Aromatic L-Amino Acid DecarboxylaseAADC
Dopamine Beta-HydroxylaseDBH
Phenylethanolamine N-methyltransferasePNMT
AgentMechanism
PropranololBeta-adrenergic antagonist
PrazosinAlpha1-adrenergic antagonist
ClonidineAlpha2-adrenergic agonist
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-4ec3184d data_in benchmark_ot_ad_answer_key:PNMT
benchmark_ot_ad_answer_key:PNMT data_in ent-gene-4ec3184d