| Gene Symbol | ent-gene-380a5cd8 |
| Function | ### Neural Stem Cell Maintenance |
| HMG (High Mobility Group) domain | DNA binding (~80 aa, residues 41-120) |
| Transactivation domain | C-terminal region for transcriptional activation |
| Dimerization domain | For cooperative DNA binding |
| Nuclear localization signals | NLS1 (positions 41-52), NLS2 (positions 116-127) |
| SOX binding motif | (A/T)(A/T)CAA(A/T)G (often abbreviated as Sox binding sites) |
| Cooperative binding | Often with partner transcription factors (OCT4, PAX6) |
| Enhancer activation | Long-range chromatin interactions |
| Stemness | Oct4, Nestin, Sox2 itself (autoregulation) |
| Neurogenesis | NeuroD1, Ascl1, Map2 |
| Pluripotency maintenance | Oct4,Utf1 |
| Cellular adhesion | Cdh1, Cdh2 |
| Signaling pathways | Fgf4, Wnt1 |
| OCT4 (POU5F1) | Pluripotency circuit |
| PAX6 | Neural fate specification |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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